Times Reported Time consuming queries #1

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[ User: pub1 - Total duration: 8s389ms - Times executed: 1 ]

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select distinct chemTerm.acc_txt # 015, chemTerm.nm # 015, 'chemical' # 015, diseaseTerm.acc_txt # 015, diseaseTerm.nm # 015, 'disease' # 015, cdr.source_cd # 015 from pub1.CHEM_DISEASE_REFERENCE cdr # 015, pub1.TERM chemTerm # 015, pub1.TERM diseaseTerm # 015 where cdr.disease_id = diseaseTerm.id # 015 and cdr.chem_id = chemTerm.id # 015 and diseaseTerm.id in ( select descendant_object_id from pub1.DAG_PATH where ancestor_object_id = # 015 ( select id from pub1.TERM where nm = 'Amyotrophic Lateral Sclerosis' and object_type_id = 3)) # 015;

Date: 2026-03-25 16:27:26
Duration: 8s389ms
Database: ctddev51
User: pub1
Bind query: yes

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Times Reported Time consuming queries #2

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[ User: pub1 - Total duration: 8s59ms - Times executed: 1 ]

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select distinct geneTerm.acc_txt ,geneTerm.nm ,'gene' ,chemTerm.acc_txt ,chemTerm.nm ,'chemical' from pub1.GENE_CHEM_REFERENCE gcr ,pub1.TERM geneTerm ,pub1.TERM chemTerm where gcr.gene_id = geneTerm.id and gcr.chem_id = chemTerm.id and ( gcr.chem_id IN ( SELECT id FROM term WHERE nm IN ( -- genes 'NOG' ,'TNF' ,'INS' ,'CASP3' ,'IL1B' ,'IL6' ,'MAPK1' ,'NFE2L2' ,'MAPK3' ,'HMOX1' ,'AHR' ,'CYP1A1' ,'PTGS2' ,'PPARA' ,'BCL2' ,'CAT' ,'ESR1' ,'BAX' ,'NOS2' ,'RELA' ,'TGFB1' ,'TP53' ,'RORA' ,'AKT1' ,'CXCL8' ,'PPARG' ,'IFNG' ,'AR' ,'INS1' ,'ACHE' ,'PARP1' ,'CASP9' ,'CCL2' ,'NQO1' ,'CDKN1A' ,'CYP3A4' ,'MMP9' ,'SOD2' ,'APP' ,'VEGFA' ,'CYP1A2' ,'CCND1' ,'FOS' ,'NFKBIA' ,'SOD1' ,'HIF1A' ,'DDIT3' ,'ESR2' ,'JUN' ,'IL10' ,'AGT' ,'FGF2' ,'ABCB1' ,'CYP2E1' ,'GPT' ,'NR1I3' ,'CYP1B1' ,'CASP8' ,'NR1I2' ,'MAPK8' ,'EGF' ,'SIRT1' ,'GSR' ,'ACTA2' ,'MPO' ,'MYC' ,'ICAM1' ,'HSPA5' ,'MMP2' ,'G3BP1' ,'STAT3' ,'SQSTM1' ,'EGFR' ,'IL4' ,'NFKB1' ,'TLR4' ,'CASP1' ,'ALB' ,'RX3' ,'CTNNB1' ,'NOS3' ,'IGF1' ,'BCL2L1' ,'COL1A1' ,'GCLC' ,'NLRP3' ,'MAP1LC3B' ,'CDH1' ,'SREBF1' ,'GSK3B' ,'MTOR' ,'FASN' ,'PCNA' ,'ABCC2' ,'STAR' ,'PGR' ,'BDNF' ,'PPARGC1A' ,'CYP19A1' ,'GPX1' ,'H2AX' ,'LEP' ,'VIM' ,'IL18' ,'OGA' ,'GSTP1' ,'ADIPOQ' ,'BECN1' ,'IL1A' ,'TRP53' ,'FAS' ,'EGR1' ,'VCAM1' ,'NR1H4' ,'NR3C1' ,'APOE' ,'ABCG2' ,'FN1' ,'MYD88' ,'IL2' ,'CXCL1' ,'FSHB' ,'CREB1' ,'EDN1' ,'BIRC5' ,'SERPINE1' ,'ABCC1' ,'CNR1' ,'ABCB11' ,'CYCS' ,'CD36' ,'TIMP1' ,'GCLM' ,'CYP2C9' ,'TNFSF10' ,'LHB' ,'TH' ,'CXCL2' ,'FABP4' ,'BCHE' ,'ATF4' ,'PON1' ,'CYP11A1' ,'SPP1' ,'CASP7' ,'HMGCR' ,'MAPK9' ,'IL12B' ,'CYP17A1' ,'CCNB1' ,'CDKN1B' ,'CYP2B6' ,'RB1' ,'PRL' ,'MAPK14' ,'CEBPB' ,'CXCL10' ,'TIPARP' ,'GADD45A' ,'XBP1' ,'ATF3' ,'TRPV1' ,'CDK1' ,'MT1' ,'LPL' ,'GJA1' ,'MKI67' ,'MAPT' ,'ADRB2' ,'PTEN' ,'TXNRD1' ,'CPT1A' ,'KEAP1' ,'CYP7A1' ,'SLC2A1' ,'CCL5' ,'RPS6KB1' ,'ACACA' ,'KCNH2' ,'CEBPA' ,'STAT1' ,'INHBA' ,'MCL1' ,'BMP4' ,'CCN2' ,'SRC' ,'CSF2' ,'PTGS1' ,'EIF2AK3' ,'XDH' ,'SNCA' ,'ABCA1' ,'CDK2' ,'GPX4' ,'THRB' ,'CNR2' ,'DRD2' ,'LDLR' ,'GSTM1' ,'ABCC3' -- chemicals ,'bisphenol A' ,'Tetrachlorodibenzodioxin' ,'Benzo(a)pyrene' ,'Valproic Acid' ,'sodium arsenite' ,'Lipopolysaccharides' ,'Estradiol' ,'Acetaminophen' ,'4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide' ,'dorsomorphin' ,'Particulate Matter' ,'Dexamethasone' ,'Cadmium Chloride' ,'titanium dioxide' ,'Aflatoxin B1' ,'Air Pollutants' ,'Cisplatin' ,'Tobacco Smoke Pollution' ,'Carbon Tetrachloride' ,'Resveratrol' ,'Doxorubicin' ,'pirinixic acid' ,'Ethinyl Estradiol' ,'Ozone' ,'Tretinoin' ,'Ethanol' ,'Dietary Fats' ,'Thioacetamide' ,'Cyclosporine' ,'Nanotubes, Carbon' ,'perfluorooctane sulfonic acid' ,'bisphenol S' ,'Folic Acid' ,'Vehicle Emissions' ,'1,2-Dimethylhydrazine' ,'Oxygen' ,'trichostatin A' ,'1-Methyl-3-isobutylxanthine' ,'Silicon Dioxide' ,'Indomethacin' ,'bisphenol F' ,'CGP 52608' ,'Atrazine' ,'Arsenic Trioxide' ,'methylmercuric chloride' ,'Cadmium' ,'Phenobarbital' ,'arsenite' ,'decamethrin' ,'Paraquat' ,'Tetradecanoylphorbol Acetate' ,'Quercetin' ,'Propylthiouracil' ,'Hydrogen Peroxide' ,'perfluorooctanoic acid' ,'Glucose' ,'Copper' ,'Smoke' ,'Chlorpyrifos' ,'triphenyl phosphate' ,'Gentamicins' ,'Diethylhexyl Phthalate' ,'Arsenic' ,'Rotenone' ,'Diethylnitrosamine' ,'Testosterone' ,'Acrylamide' ,'Phenylmercuric Acetate' ,'Dibutyl Phthalate' ,'Streptozocin' ,'Progesterone' ,'Plant Extracts' ,'Trichloroethylene' ,'aristolochic acid I' ,'Copper Sulfate' ,'cobaltous chloride' ,'Methyl Methanesulfonate' ,'Methamphetamine' ,'(+)-JQ1 compound' ,'jinfukang' ,'deoxynivalenol' ,'vinclozolin' ,'abrine' ,'Nickel' ,'Dioxins' ,'Genistein' ,'Fulvestrant' ,'Clofibrate' ,'Rosiglitazone' ,'Soot' ,'Cocaine' ,'Sunitinib' ,'Dronabinol' ,'Methotrexate' ,'JP8 aviation fuel' ,'triptonide' ,'entinostat' ,'2,2'',4,4''-tetrabromodiphenyl ether' ,'Tamoxifen' ,'Acetylcysteine' ,'1-Methyl-4-phenylpyridinium' ,'Calcitriol' ,'Acrolein' ,'di-n-butylphosphoric acid' ,'Thiram' ,'Endosulfan' ,'Zinc' ,'Ammonium Chloride' ,'Choline' ,'Ionomycin' ,'Formaldehyde' ,'tris(1,3-dichloro-2-propyl)phosphate' ,'Caffeine' ,'potassium chromate(VI)' ,'Methionine' ,'lead acetate' ,'perfluorooctanesulfonamide' ,'lipopolysaccharide, E coli O55-B5' ,'Flutamide' ,'Vorinostat' ,'furan' ,'Ivermectin' ,'Curcumin' ,'Lead' ,'Urethane' ,'Troglitazone' ,'S-(1,2-dichlorovinyl)cysteine' ,'Fluorouracil' ,'Fenretinide' ,'ethylene dichloride' ,'Dextran Sulfate' ,'hexabromocyclododecane' ,'Asbestos, Crocidolite' ,'7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide' ,'sodium arsenate' ,'manganese chloride' ,'lipopolysaccharide, Escherichia coli O111 B4' ,'Cuprizone' ,'Methapyrilene' ,'Topotecan' ,'Isoproterenol' ,'epoxiconazole' ,'FR900359' ,'Methimazole' ,'Nicotine' ,'Antirheumatic Agents' ,'3,4,5,3'',4''-pentachlorobiphenyl' ,'methacrylaldehyde' ,'chromium hexavalent ion' ,'Triclosan' ,'Glyphosate' ,'N-Methyl-3,4-methylenedioxyamphetamine' ,'mono-(2-ethylhexyl)phthalate' ,'Aluminum' ,'Oxaliplatin' ,'T-2 Toxin' ,'Cellulose' ,'Decitabine' ,'acetamide' ,'Amitrole' ,'beta-lapachone' ,'Cyclophosphamide' ,'butyraldehyde' ,'Selenium' ,'alpha-pinene' ,'Temozolomide' ,'Amiodarone' ,'4,4''-diaminodiphenylmethane' ,'1,4-bis(2-(3,5-dichloropyridyloxy))benzene' ,'Panobinostat' ,'Diethylstilbestrol' ,'decabromobiphenyl ether' ,'Tunicamycin' ,'Carbamazepine' ,'Lactic Acid' ,'Sodium Fluoride' ,'Cannabidiol' ,'ochratoxin A' ,'epigallocatechin gallate' ,'1-Naphthylisothiocyanate' ,'fipronil' ,'Mercuric Chloride' ,'Coumestrol' ,'Paclitaxel' ,'bisphenol AF' ,'tert-Butylhydroperoxide' ,'dicrotophos' ,'sulforaphane' ,'Enzyme Inhibitors' ,'Dichlorodiphenyl Dichloroethylene' ,'1H,1H,10H,10H-perfluorodecane-1,10-diol' ,'Methoxychlor' ,'Thapsigargin' ,'Leflunomide' ,'Haloperidol' ,'2,4,5,2'',4'',5''-hexachlorobiphenyl' ,'9,10-Dimethyl-1,2-benzanthracene' ,'Silver' -- diseases ,'Chemical and Drug Induced Liver Injury' ,'Seizures' ,'Hypertension' ,'Hypotension' ,'Kidney Diseases' ,'Pain' ,'Acute Kidney Injury' ,'Breast Neoplasms' ,'Necrosis' ,'Weight Loss' ,'Inflammation' ,'Drug-Related Side Effects and Adverse Reactions' ,'Cocaine-Related Disorders' ,'Heart Failure' ,'Substance Withdrawal Syndrome' ,'Depressive Disorder' ,'Bradycardia' ,'Prostatic Neoplasms' ,'Hyperalgesia' ,'Prenatal Exposure Delayed Effects' ,'Myocardial Infarction' ,'Catalepsy' ,'Liver Cirrhosis, Experimental' ,'Hyperkinesis' ,'Edema' ,'Arrhythmias, Cardiac' ,'Carcinoma, Hepatocellular' ,'Dyskinesia, Drug-Induced' ,'Nausea' ,'Vomiting' ,'Lung Neoplasms' ,'Disease Models, Animal' ,'Hyperglycemia' ,'Hepatomegaly' ,'Weight Gain' ,'Cardiomyopathies' ,'Tachycardia' ,'Headache' ,'Bipolar Disorder' ,'Nerve Degeneration' ,'Proteinuria' ,'Diabetes Mellitus, Experimental' ,'Anemia' ,'Memory Disorders' ,'Tremor' ,'Peripheral Nervous System Diseases' ,'Fatty Liver' ,'Parkinson Disease' ,'Liver Neoplasms' ,'Status Epilepticus' ,'Schizophrenia' ,'Thrombocytopenia' ,'Liver Neoplasms, Experimental' ,'Cognition Disorders' ,'Heart Diseases' ,'Hemorrhage' ,'Arthritis, Rheumatoid' ,'Renal Insufficiency' ,'Fever' ,'Asthma' ,'Cholestasis' ,'Insulin Resistance' ,'Urinary Bladder Neoplasms' ,'Obesity' ,'Nervous System Diseases' ,'Liver Cirrhosis' ,'Poisoning' ,'Muscular Diseases' ,'Diarrhea' ,'Neoplasms, Experimental' ,'Colorectal Neoplasms' ,'Atrial Fibrillation' ,'Neutropenia' ,'Tachycardia, Ventricular' ,'Anxiety Disorders' ,'Colonic Neoplasms' ,'Epilepsy' ,'Myocardial Ischemia' ,'Stomach Neoplasms' ,'Amnesia' ,'Cardiomegaly' ,'Brain Injuries' ,'Parkinsonian Disorders' ,'Diabetes Mellitus, Type 2' ,'Neoplasm Metastasis' ,'Melanoma' ,'Neoplasm Invasiveness' ,'Torsades de Pointes' ,'Neoplasms' ,'Long QT Syndrome' ,'Ventricular Dysfunction, Left' ,'Cell Transformation, Neoplastic' ,'Thrombosis' ,'Pain, Postoperative' ,'Movement Disorders' ,'Hallucinations' ,'Dystonia' ,'Nephritis, Interstitial' ,'Stomach Ulcer' ,'Carcinoma, Non-Small-Cell Lung' ,'Pulmonary Fibrosis' ,'Brain Diseases' ,'Fibrosis' ,'Learning Disabilities' ,'Heart Arrest' ,'Drug Hypersensitivity' ,'Liver Diseases' ,'Psychoses, Substance-Induced' ,'Dizziness' ,'Cardiovascular Diseases' ,'Hypokalemia' ,'Ventricular Fibrillation' ,'Autistic Disorder' ,'Precursor Cell Lymphoblastic Leukemia-Lymphoma' ,'Myoclonus' ,'Hyperplasia' ,'Precancerous Conditions' ,'Multiple Myeloma' ,'Angina Pectoris' ,'Neurotoxicity Syndromes' ,'Liver Failure, Acute' ,'Leukemia, Promyelocytic, Acute' ,'Adenocarcinoma' ,'Basal Ganglia Diseases' ,'Cystitis' ,'Hepatitis B' ,'Hepatitis' ,'Dermatitis, Allergic Contact' ,'Leukemia, Myeloid, Acute' ,'Lung Injury' ,'HIV Infections' ,'Ataxia' ,'Ovarian Neoplasms' ,'Atherosclerosis' ,'Mammary Neoplasms, Experimental' ,'Abnormalities, Drug-Induced' ,'Confusion' ,'Staphylococcal Infections' ,'Autism Spectrum Disorder' ,'Stroke' ,'Leukopenia' ,'Testicular Diseases' ,'Reperfusion Injury' ,'Colitis' ,'Alzheimer Disease' ,'Carcinoma' ,'Glucose Intolerance' ,'Skin Neoplasms' ,'Anemia, Hemolytic' ,'Exanthema' ,'Hypertension, Pulmonary' ,'Muscle Rigidity' ,'Psychotic Disorders' ,'Hypercholesterolemia' ,'Angioedema' ,'Delirium' ,'Non-alcoholic Fatty Liver Disease' ,'Paralysis' ,'Apnea' ,'Pulmonary Edema' ,'Pneumonia' ,'Micronuclei, Chromosome-Defective' ,'Venous Thrombosis' ,'Parkinson Disease, Secondary' ,'Nephrotic Syndrome' ,'Muscle Weakness' ,'Pruritus' ,'Drug Eruptions' ,'Acute Lung Injury' ,'Hypothermia' ,'Pancreatic Neoplasms' ,'Diabetic Nephropathies' ,'Gastrointestinal Diseases' ,'Substance-Related Disorders' ,'Coma' ,'Epilepsy, Tonic-Clonic' ,'Craniofacial Abnormalities' ,'Stevens-Johnson Syndrome' ,'Migraine Disorders' ,'Vision Disorders' ,'Jaundice' ,'Paresthesia' ,'Carcinoma, Squamous Cell' ,'Fatigue' ,'Cerebral Hemorrhage' ,'Hypercalcemia' ,'Skin Diseases' ,'Hypotension, Orthostatic' ,'Urticaria' ,'Hematuria' ,'Erectile Dysfunction' ,'Colitis, Ulcerative' ,'Mammary Neoplasms, Animal' ,'Lung Diseases' ,'Rhabdomyolysis' ,'Oligospermia' ,'Depressive Disorder, Major' ,'Anemia, Aplastic' ,'Anorexia' ,'Hyperlipidemias' -- phenotypes ,'apoptotic process' ,'cell population proliferation' ,'cellular metabolic process' ,'lipid oxidation' ,'glutathione metabolic process' ,'reactive oxygen species metabolic process' ,'lipid catabolic process' ,'cell death' ,'detection of oxidative stress' ,'positive regulation of apoptotic process' ,'superoxide dismutase activity' ,'positive regulation of reactive oxygen species biosynthetic process' ,'positive regulation of cell death' ,'regulation of blood pressure' ,'reactive oxygen species biosynthetic process' ,'negative regulation of cell population proliferation' ,'regulation of mitochondrial membrane potential' ,'vasoconstriction' ,'glutathione biosynthetic process' ,'membrane lipid catabolic process' ,'glutathione peroxidase activity' ,'cellular response to DNA damage stimulus' ,'cholesterol metabolic process' ,'positive regulation of cell population proliferation' ,'triglyceride metabolic process' ,'response to oxidative stress' ,'regulation of heart rate' ,'negative regulation of mitotic cell cycle' ,'vasodilation' ,'ATP metabolic process' ,'cell growth' ,'cellular calcium ion homeostasis' ,'leukocyte migration involved in inflammatory response' ,'nitric oxide metabolic process' ,'creatinine metabolic process' ,'apoptotic DNA fragmentation' ,'lipid droplet formation' ,'ncRNA transcription' ,'protein oxidation' ,'mitotic cell cycle process' ,'DNA modification' ,'inflammatory response' ,'cholesterol homeostasis' ,'glutathione transferase activity' ,'autophagy' ,'fat cell differentiation' ,'triglyceride homeostasis' ,'lipid metabolic process' ,'necrotic cell death' ,'xenobiotic metabolic process' ,'negative regulation of superoxide dismutase activity' ,'triglyceride biosynthetic process' ,'cell migration' ,'cell redox homeostasis' ,'bile acid metabolic process' ,'nitric oxide biosynthetic process' ,'superoxide anion generation' ,'lactate dehydrogenase activity' ,'cell cycle' ,'amino acid metabolic process' ,'testosterone biosynthetic process' ,'activation of protein kinase B activity' ,'L-aspartate:2-oxoglutarate aminotransferase activity' ,'positive regulation of nitric oxide biosynthetic process' ,'cholesterol biosynthetic process' ,'protein import into nucleus' ,'positive regulation of protein import into nucleus' ,'wound healing, spreading of cells' ,'alkaline phosphatase activity' ,'positive regulation of cytosolic calcium ion concentration' ,'glucose homeostasis' ,'positive regulation of mitochondrial membrane potential' ,'fatty acid metabolic process' ,'cell chemotaxis' ,'positive regulation of vasoconstriction' ,'spermatogenesis' ,'positive regulation of neuron death' ,'positive regulation of superoxide dismutase activity' ,'collagen fibril organization' ,'cell differentiation' ,'histone H3-K9 acetylation' ,'mitochondrion organization' ,'positive regulation of protein localization to nucleus' ,'positive regulation of p38MAPK cascade' ,'ATP biosynthetic process' ,'metabolic process' ,'locomotion involved in locomotory behavior' ,'urate metabolic process' ,'dopamine metabolic process' ,'positive regulation of NF-kappaB transcription factor activity' ,'embryo development' ,'lipid biosynthetic process' ,'protein lipidation' ,'histamine secretion mediated by immunoglobulin' ,'glucose metabolic process' ,'negative regulation of mitochondrial membrane potential' ,'release of cytochrome c from mitochondria' ,'DNA catabolic process, endonucleolytic' ,'cellular respiration' ,'calcium ion homeostasis' ,'positive regulation of cell migration' ,'regulation of cellular metabolic process' ,'reactive nitrogen species metabolic process' ,'positive regulation of inflammatory response' ,'establishment of protein localization to plasma membrane' ,'lipid homeostasis' ,'response to antineoplastic agent' ,'glucose import' ,'urea metabolic process' ,'positive regulation of ERK1 and ERK2 cascade' ,'positive regulation of necrotic cell death' ,'memory' ,'negative regulation of glutathione peroxidase activity' ,'positive regulation of apoptotic DNA fragmentation' ,'mitochondrial depolarization' ,'G2/M transition of mitotic cell cycle' ,'cAMP metabolic process' ,'mitotic S phase' ,'hydrogen peroxide biosynthetic process' ,'positive regulation of superoxide anion generation' ,'positive regulation of autophagy' ,'protein modification process' ,'regulation of metabolic process' ,'cellular iron ion homeostasis' ,'lactate metabolic process' ,'DNA methylation on cytosine within a CG sequence' ,'apoptotic chromosome condensation' ,'serotonin metabolic process' ,'cellular lipid metabolic process' ,'positive regulation of glutathione peroxidase activity' ,'transepithelial transport' ,'positive regulation of lipid storage' ,'hydrogen peroxide metabolic process' ,'G0 to G1 transition' ,'positive regulation of collagen biosynthetic process' ,'iron ion homeostasis' ,'positive regulation of cytolysis' ,'gluconeogenesis' ,'micronucleus organization' ,'microglial cell activation' ,'positive regulation of autophagosome assembly' ,'positive regulation of NIK/NF-kappaB signaling' ,'calcium-mediated signaling' ,'positive regulation of cytokine production involved in inflammatory response' ,'cellular senescence' ,'neuron death' ,'macrophage activation' ,'cAMP biosynthetic process' ,'positive regulation of lipid catabolic process' ,'negative regulation of response to drug' ,'calcium ion import' ,'behavioral response to pain' ,'positive regulation of intracellular estrogen receptor signaling pathway' ,'regulation of bile acid metabolic process' ,'mitotic cell cycle' ,'autophagosome assembly' ,'prostaglandin metabolic process' ,'protein poly-ADP-ribosylation' ,'DNA methylation' ,'glycolytic process' ,'positive regulation of fat cell differentiation' ,'protein lipidation involved in autophagosome assembly' ,'estrogen metabolic process' ,'thyroid hormone metabolic process' ,'positive regulation of organ growth' ,'neutrophil migration' ,'NADH dehydrogenase (ubiquinone) activity' ,'prostaglandin biosynthetic process' ,'negative regulation of ATP biosynthetic process' ,'adipose tissue development' ,'larval development' ,'androgen metabolic process' ,'amino acid biosynthetic process' ,'aerobic respiration' ,'positive regulation of cellular extravasation' ,'positive regulation of neutrophil extravasation' ,'negative regulation of cell migration' ,'carbohydrate metabolic process' ,'positive regulation of JNK cascade' ,'positive regulation of neuron apoptotic process' ,'positive regulation of release of cytochrome c from mitochondria' ,'cognition' ,'vacuole organization' ,'renal sodium excretion' ,'osteoclast differentiation' ,'positive regulation of epithelial to mesenchymal transition' ,'glutathione derivative biosynthetic process' ,'arachidonic acid metabolic process' ,'neurotransmitter metabolic process' ,'stress granule assembly' ,'sperm motility' ,'hepatocyte differentiation' ,'AMP-activated protein kinase activity' ,'swimming behavior' ,'negative regulation of monooxygenase activity' ,'fatty acid homeostasis' ,'L-ascorbic acid metabolic process' ,'pyroptosis' ,'response to xenobiotic stimulus' ,'positive regulation of prostaglandin biosynthetic process' ) ) and gcr.gene_id IN ( SELECT id FROM term WHERE nm IN ( -- genes 'NOG' ,'TNF' ,'INS' ,'CASP3' ,'IL1B' ,'IL6' ,'MAPK1' ,'NFE2L2' ,'MAPK3' ,'HMOX1' ,'AHR' ,'CYP1A1' ,'PTGS2' ,'PPARA' ,'BCL2' ,'CAT' ,'ESR1' ,'BAX' ,'NOS2' ,'RELA' ,'TGFB1' ,'TP53' ,'RORA' ,'AKT1' ,'CXCL8' ,'PPARG' ,'IFNG' ,'AR' ,'INS1' ,'ACHE' ,'PARP1' ,'CASP9' ,'CCL2' ,'NQO1' ,'CDKN1A' ,'CYP3A4' ,'MMP9' ,'SOD2' ,'APP' ,'VEGFA' ,'CYP1A2' ,'CCND1' ,'FOS' ,'NFKBIA' ,'SOD1' ,'HIF1A' ,'DDIT3' ,'ESR2' ,'JUN' ,'IL10' ,'AGT' ,'FGF2' ,'ABCB1' ,'CYP2E1' ,'GPT' ,'NR1I3' ,'CYP1B1' ,'CASP8' ,'NR1I2' ,'MAPK8' ,'EGF' ,'SIRT1' ,'GSR' ,'ACTA2' ,'MPO' ,'MYC' ,'ICAM1' ,'HSPA5' ,'MMP2' ,'G3BP1' ,'STAT3' ,'SQSTM1' ,'EGFR' ,'IL4' ,'NFKB1' ,'TLR4' ,'CASP1' ,'ALB' ,'RX3' ,'CTNNB1' ,'NOS3' ,'IGF1' ,'BCL2L1' ,'COL1A1' ,'GCLC' ,'NLRP3' ,'MAP1LC3B' ,'CDH1' ,'SREBF1' ,'GSK3B' ,'MTOR' ,'FASN' ,'PCNA' ,'ABCC2' ,'STAR' ,'PGR' ,'BDNF' ,'PPARGC1A' ,'CYP19A1' ,'GPX1' ,'H2AX' ,'LEP' ,'VIM' ,'IL18' ,'OGA' ,'GSTP1' ,'ADIPOQ' ,'BECN1' ,'IL1A' ,'TRP53' ,'FAS' ,'EGR1' ,'VCAM1' ,'NR1H4' ,'NR3C1' ,'APOE' ,'ABCG2' ,'FN1' ,'MYD88' ,'IL2' ,'CXCL1' ,'FSHB' ,'CREB1' ,'EDN1' ,'BIRC5' ,'SERPINE1' ,'ABCC1' ,'CNR1' ,'ABCB11' ,'CYCS' ,'CD36' ,'TIMP1' ,'GCLM' ,'CYP2C9' ,'TNFSF10' ,'LHB' ,'TH' ,'CXCL2' ,'FABP4' ,'BCHE' ,'ATF4' ,'PON1' ,'CYP11A1' ,'SPP1' ,'CASP7' ,'HMGCR' ,'MAPK9' ,'IL12B' ,'CYP17A1' ,'CCNB1' ,'CDKN1B' ,'CYP2B6' ,'RB1' ,'PRL' ,'MAPK14' ,'CEBPB' ,'CXCL10' ,'TIPARP' ,'GADD45A' ,'XBP1' ,'ATF3' ,'TRPV1' ,'CDK1' ,'MT1' ,'LPL' ,'GJA1' ,'MKI67' ,'MAPT' ,'ADRB2' ,'PTEN' ,'TXNRD1' ,'CPT1A' ,'KEAP1' ,'CYP7A1' ,'SLC2A1' ,'CCL5' ,'RPS6KB1' ,'ACACA' ,'KCNH2' ,'CEBPA' ,'STAT1' ,'INHBA' ,'MCL1' ,'BMP4' ,'CCN2' ,'SRC' ,'CSF2' ,'PTGS1' ,'EIF2AK3' ,'XDH' ,'SNCA' ,'ABCA1' ,'CDK2' ,'GPX4' ,'THRB' ,'CNR2' ,'DRD2' ,'LDLR' ,'GSTM1' ,'ABCC3' -- chemicals ,'bisphenol A' ,'Tetrachlorodibenzodioxin' ,'Benzo(a)pyrene' ,'Valproic Acid' ,'sodium arsenite' ,'Lipopolysaccharides' ,'Estradiol' ,'Acetaminophen' ,'4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide' ,'dorsomorphin' ,'Particulate Matter' ,'Dexamethasone' ,'Cadmium Chloride' ,'titanium dioxide' ,'Aflatoxin B1' ,'Air Pollutants' ,'Cisplatin' ,'Tobacco Smoke Pollution' ,'Carbon Tetrachloride' ,'Resveratrol' ,'Doxorubicin' ,'pirinixic acid' ,'Ethinyl Estradiol' ,'Ozone' ,'Tretinoin' ,'Ethanol' ,'Dietary Fats' ,'Thioacetamide' ,'Cyclosporine' ,'Nanotubes, Carbon' ,'perfluorooctane sulfonic acid' ,'bisphenol S' ,'Folic Acid' ,'Vehicle Emissions' ,'1,2-Dimethylhydrazine' ,'Oxygen' ,'trichostatin A' ,'1-Methyl-3-isobutylxanthine' ,'Silicon Dioxide' ,'Indomethacin' ,'bisphenol F' ,'CGP 52608' ,'Atrazine' ,'Arsenic Trioxide' ,'methylmercuric chloride' ,'Cadmium' ,'Phenobarbital' ,'arsenite' ,'decamethrin' ,'Paraquat' ,'Tetradecanoylphorbol Acetate' ,'Quercetin' ,'Propylthiouracil' ,'Hydrogen Peroxide' ,'perfluorooctanoic acid' ,'Glucose' ,'Copper' ,'Smoke' ,'Chlorpyrifos' ,'triphenyl phosphate' ,'Gentamicins' ,'Diethylhexyl Phthalate' ,'Arsenic' ,'Rotenone' ,'Diethylnitrosamine' ,'Testosterone' ,'Acrylamide' ,'Phenylmercuric Acetate' ,'Dibutyl Phthalate' ,'Streptozocin' ,'Progesterone' ,'Plant Extracts' ,'Trichloroethylene' ,'aristolochic acid I' ,'Copper Sulfate' ,'cobaltous chloride' ,'Methyl Methanesulfonate' ,'Methamphetamine' ,'(+)-JQ1 compound' ,'jinfukang' ,'deoxynivalenol' ,'vinclozolin' ,'abrine' ,'Nickel' ,'Dioxins' ,'Genistein' ,'Fulvestrant' ,'Clofibrate' ,'Rosiglitazone' ,'Soot' ,'Cocaine' ,'Sunitinib' ,'Dronabinol' ,'Methotrexate' ,'JP8 aviation fuel' ,'triptonide' ,'entinostat' ,'2,2'',4,4''-tetrabromodiphenyl ether' ,'Tamoxifen' ,'Acetylcysteine' ,'1-Methyl-4-phenylpyridinium' ,'Calcitriol' ,'Acrolein' ,'di-n-butylphosphoric acid' ,'Thiram' ,'Endosulfan' ,'Zinc' ,'Ammonium Chloride' ,'Choline' ,'Ionomycin' ,'Formaldehyde' ,'tris(1,3-dichloro-2-propyl)phosphate' ,'Caffeine' ,'potassium chromate(VI)' ,'Methionine' ,'lead acetate' ,'perfluorooctanesulfonamide' ,'lipopolysaccharide, E coli O55-B5' ,'Flutamide' ,'Vorinostat' ,'furan' ,'Ivermectin' ,'Curcumin' ,'Lead' ,'Urethane' ,'Troglitazone' ,'S-(1,2-dichlorovinyl)cysteine' ,'Fluorouracil' ,'Fenretinide' ,'ethylene dichloride' ,'Dextran Sulfate' ,'hexabromocyclododecane' ,'Asbestos, Crocidolite' ,'7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide' ,'sodium arsenate' ,'manganese chloride' ,'lipopolysaccharide, Escherichia coli O111 B4' ,'Cuprizone' ,'Methapyrilene' ,'Topotecan' ,'Isoproterenol' ,'epoxiconazole' ,'FR900359' ,'Methimazole' ,'Nicotine' ,'Antirheumatic Agents' ,'3,4,5,3'',4''-pentachlorobiphenyl' ,'methacrylaldehyde' ,'chromium hexavalent ion' ,'Triclosan' ,'Glyphosate' ,'N-Methyl-3,4-methylenedioxyamphetamine' ,'mono-(2-ethylhexyl)phthalate' ,'Aluminum' ,'Oxaliplatin' ,'T-2 Toxin' ,'Cellulose' ,'Decitabine' ,'acetamide' ,'Amitrole' ,'beta-lapachone' ,'Cyclophosphamide' ,'butyraldehyde' ,'Selenium' ,'alpha-pinene' ,'Temozolomide' ,'Amiodarone' ,'4,4''-diaminodiphenylmethane' ,'1,4-bis(2-(3,5-dichloropyridyloxy))benzene' ,'Panobinostat' ,'Diethylstilbestrol' ,'decabromobiphenyl ether' ,'Tunicamycin' ,'Carbamazepine' ,'Lactic Acid' ,'Sodium Fluoride' ,'Cannabidiol' ,'ochratoxin A' ,'epigallocatechin gallate' ,'1-Naphthylisothiocyanate' ,'fipronil' ,'Mercuric Chloride' ,'Coumestrol' ,'Paclitaxel' ,'bisphenol AF' ,'tert-Butylhydroperoxide' ,'dicrotophos' ,'sulforaphane' ,'Enzyme Inhibitors' ,'Dichlorodiphenyl Dichloroethylene' ,'1H,1H,10H,10H-perfluorodecane-1,10-diol' ,'Methoxychlor' ,'Thapsigargin' ,'Leflunomide' ,'Haloperidol' ,'2,4,5,2'',4'',5''-hexachlorobiphenyl' ,'9,10-Dimethyl-1,2-benzanthracene' ,'Silver' -- diseases ,'Chemical and Drug Induced Liver Injury' ,'Seizures' ,'Hypertension' ,'Hypotension' ,'Kidney Diseases' ,'Pain' ,'Acute Kidney Injury' ,'Breast Neoplasms' ,'Necrosis' ,'Weight Loss' ,'Inflammation' ,'Drug-Related Side Effects and Adverse Reactions' ,'Cocaine-Related Disorders' ,'Heart Failure' ,'Substance Withdrawal Syndrome' ,'Depressive Disorder' ,'Bradycardia' ,'Prostatic Neoplasms' ,'Hyperalgesia' ,'Prenatal Exposure Delayed Effects' ,'Myocardial Infarction' ,'Catalepsy' ,'Liver Cirrhosis, Experimental' ,'Hyperkinesis' ,'Edema' ,'Arrhythmias, Cardiac' ,'Carcinoma, Hepatocellular' ,'Dyskinesia, Drug-Induced' ,'Nausea' ,'Vomiting' ,'Lung Neoplasms' ,'Disease Models, Animal' ,'Hyperglycemia' ,'Hepatomegaly' ,'Weight Gain' ,'Cardiomyopathies' ,'Tachycardia' ,'Headache' ,'Bipolar Disorder' ,'Nerve Degeneration' ,'Proteinuria' ,'Diabetes Mellitus, Experimental' ,'Anemia' ,'Memory Disorders' ,'Tremor' ,'Peripheral Nervous System Diseases' ,'Fatty Liver' ,'Parkinson Disease' ,'Liver Neoplasms' ,'Status Epilepticus' ,'Schizophrenia' ,'Thrombocytopenia' ,'Liver Neoplasms, Experimental' ,'Cognition Disorders' ,'Heart Diseases' ,'Hemorrhage' ,'Arthritis, Rheumatoid' ,'Renal Insufficiency' ,'Fever' ,'Asthma' ,'Cholestasis' ,'Insulin Resistance' ,'Urinary Bladder Neoplasms' ,'Obesity' ,'Nervous System Diseases' ,'Liver Cirrhosis' ,'Poisoning' ,'Muscular Diseases' ,'Diarrhea' ,'Neoplasms, Experimental' ,'Colorectal Neoplasms' ,'Atrial Fibrillation' ,'Neutropenia' ,'Tachycardia, Ventricular' ,'Anxiety Disorders' ,'Colonic Neoplasms' ,'Epilepsy' ,'Myocardial Ischemia' ,'Stomach Neoplasms' ,'Amnesia' ,'Cardiomegaly' ,'Brain Injuries' ,'Parkinsonian Disorders' ,'Diabetes Mellitus, Type 2' ,'Neoplasm Metastasis' ,'Melanoma' ,'Neoplasm Invasiveness' ,'Torsades de Pointes' ,'Neoplasms' ,'Long QT Syndrome' ,'Ventricular Dysfunction, Left' ,'Cell Transformation, Neoplastic' ,'Thrombosis' ,'Pain, Postoperative' ,'Movement Disorders' ,'Hallucinations' ,'Dystonia' ,'Nephritis, Interstitial' ,'Stomach Ulcer' ,'Carcinoma, Non-Small-Cell Lung' ,'Pulmonary Fibrosis' ,'Brain Diseases' ,'Fibrosis' ,'Learning Disabilities' ,'Heart Arrest' ,'Drug Hypersensitivity' ,'Liver Diseases' ,'Psychoses, Substance-Induced' ,'Dizziness' ,'Cardiovascular Diseases' ,'Hypokalemia' ,'Ventricular Fibrillation' ,'Autistic Disorder' ,'Precursor Cell Lymphoblastic Leukemia-Lymphoma' ,'Myoclonus' ,'Hyperplasia' ,'Precancerous Conditions' ,'Multiple Myeloma' ,'Angina Pectoris' ,'Neurotoxicity Syndromes' ,'Liver Failure, Acute' ,'Leukemia, Promyelocytic, Acute' ,'Adenocarcinoma' ,'Basal Ganglia Diseases' ,'Cystitis' ,'Hepatitis B' ,'Hepatitis' ,'Dermatitis, Allergic Contact' ,'Leukemia, Myeloid, Acute' ,'Lung Injury' ,'HIV Infections' ,'Ataxia' ,'Ovarian Neoplasms' ,'Atherosclerosis' ,'Mammary Neoplasms, Experimental' ,'Abnormalities, Drug-Induced' ,'Confusion' ,'Staphylococcal Infections' ,'Autism Spectrum Disorder' ,'Stroke' ,'Leukopenia' ,'Testicular Diseases' ,'Reperfusion Injury' ,'Colitis' ,'Alzheimer Disease' ,'Carcinoma' ,'Glucose Intolerance' ,'Skin Neoplasms' ,'Anemia, Hemolytic' ,'Exanthema' ,'Hypertension, Pulmonary' ,'Muscle Rigidity' ,'Psychotic Disorders' ,'Hypercholesterolemia' ,'Angioedema' ,'Delirium' ,'Non-alcoholic Fatty Liver Disease' ,'Paralysis' ,'Apnea' ,'Pulmonary Edema' ,'Pneumonia' ,'Micronuclei, Chromosome-Defective' ,'Venous Thrombosis' ,'Parkinson Disease, Secondary' ,'Nephrotic Syndrome' ,'Muscle Weakness' ,'Pruritus' ,'Drug Eruptions' ,'Acute Lung Injury' ,'Hypothermia' ,'Pancreatic Neoplasms' ,'Diabetic Nephropathies' ,'Gastrointestinal Diseases' ,'Substance-Related Disorders' ,'Coma' ,'Epilepsy, Tonic-Clonic' ,'Craniofacial Abnormalities' ,'Stevens-Johnson Syndrome' ,'Migraine Disorders' ,'Vision Disorders' ,'Jaundice' ,'Paresthesia' ,'Carcinoma, Squamous Cell' ,'Fatigue' ,'Cerebral Hemorrhage' ,'Hypercalcemia' ,'Skin Diseases' ,'Hypotension, Orthostatic' ,'Urticaria' ,'Hematuria' ,'Erectile Dysfunction' ,'Colitis, Ulcerative' ,'Mammary Neoplasms, Animal' ,'Lung Diseases' ,'Rhabdomyolysis' ,'Oligospermia' ,'Depressive Disorder, Major' ,'Anemia, Aplastic' ,'Anorexia' ,'Hyperlipidemias' -- phenotypes ,'apoptotic process' ,'cell population proliferation' ,'cellular metabolic process' ,'lipid oxidation' ,'glutathione metabolic process' ,'reactive oxygen species metabolic process' ,'lipid catabolic process' ,'cell death' ,'detection of oxidative stress' ,'positive regulation of apoptotic process' ,'superoxide dismutase activity' ,'positive regulation of reactive oxygen species biosynthetic process' ,'positive regulation of cell death' ,'regulation of blood pressure' ,'reactive oxygen species biosynthetic process' ,'negative regulation of cell population proliferation' ,'regulation of mitochondrial membrane potential' ,'vasoconstriction' ,'glutathione biosynthetic process' ,'membrane lipid catabolic process' ,'glutathione peroxidase activity' ,'cellular response to DNA damage stimulus' ,'cholesterol metabolic process' ,'positive regulation of cell population proliferation' ,'triglyceride metabolic process' ,'response to oxidative stress' ,'regulation of heart rate' ,'negative regulation of mitotic cell cycle' ,'vasodilation' ,'ATP metabolic process' ,'cell growth' ,'cellular calcium ion homeostasis' ,'leukocyte migration involved in inflammatory response' ,'nitric oxide metabolic process' ,'creatinine metabolic process' ,'apoptotic DNA fragmentation' ,'lipid droplet formation' ,'ncRNA transcription' ,'protein oxidation' ,'mitotic cell cycle process' ,'DNA modification' ,'inflammatory response' ,'cholesterol homeostasis' ,'glutathione transferase activity' ,'autophagy' ,'fat cell differentiation' ,'triglyceride homeostasis' ,'lipid metabolic process' ,'necrotic cell death' ,'xenobiotic metabolic process' ,'negative regulation of superoxide dismutase activity' ,'triglyceride biosynthetic process' ,'cell migration' ,'cell redox homeostasis' ,'bile acid metabolic process' ,'nitric oxide biosynthetic process' ,'superoxide anion generation' ,'lactate dehydrogenase activity' ,'cell cycle' ,'amino acid metabolic process' ,'testosterone biosynthetic process' ,'activation of protein kinase B activity' ,'L-aspartate:2-oxoglutarate aminotransferase activity' ,'positive regulation of nitric oxide biosynthetic process' ,'cholesterol biosynthetic process' ,'protein import into nucleus' ,'positive regulation of protein import into nucleus' ,'wound healing, spreading of cells' ,'alkaline phosphatase activity' ,'positive regulation of cytosolic calcium ion concentration' ,'glucose homeostasis' ,'positive regulation of mitochondrial membrane potential' ,'fatty acid metabolic process' ,'cell chemotaxis' ,'positive regulation of vasoconstriction' ,'spermatogenesis' ,'positive regulation of neuron death' ,'positive regulation of superoxide dismutase activity' ,'collagen fibril organization' ,'cell differentiation' ,'histone H3-K9 acetylation' ,'mitochondrion organization' ,'positive regulation of protein localization to nucleus' ,'positive regulation of p38MAPK cascade' ,'ATP biosynthetic process' ,'metabolic process' ,'locomotion involved in locomotory behavior' ,'urate metabolic process' ,'dopamine metabolic process' ,'positive regulation of NF-kappaB transcription factor activity' ,'embryo development' ,'lipid biosynthetic process' ,'protein lipidation' ,'histamine secretion mediated by immunoglobulin' ,'glucose metabolic process' ,'negative regulation of mitochondrial membrane potential' ,'release of cytochrome c from mitochondria' ,'DNA catabolic process, endonucleolytic' ,'cellular respiration' ,'calcium ion homeostasis' ,'positive regulation of cell migration' ,'regulation of cellular metabolic process' ,'reactive nitrogen species metabolic process' ,'positive regulation of inflammatory response' ,'establishment of protein localization to plasma membrane' ,'lipid homeostasis' ,'response to antineoplastic agent' ,'glucose import' ,'urea metabolic process' ,'positive regulation of ERK1 and ERK2 cascade' ,'positive regulation of necrotic cell death' ,'memory' ,'negative regulation of glutathione peroxidase activity' ,'positive regulation of apoptotic DNA fragmentation' ,'mitochondrial depolarization' ,'G2/M transition of mitotic cell cycle' ,'cAMP metabolic process' ,'mitotic S phase' ,'hydrogen peroxide biosynthetic process' ,'positive regulation of superoxide anion generation' ,'positive regulation of autophagy' ,'protein modification process' ,'regulation of metabolic process' ,'cellular iron ion homeostasis' ,'lactate metabolic process' ,'DNA methylation on cytosine within a CG sequence' ,'apoptotic chromosome condensation' ,'serotonin metabolic process' ,'cellular lipid metabolic process' ,'positive regulation of glutathione peroxidase activity' ,'transepithelial transport' ,'positive regulation of lipid storage' ,'hydrogen peroxide metabolic process' ,'G0 to G1 transition' ,'positive regulation of collagen biosynthetic process' ,'iron ion homeostasis' ,'positive regulation of cytolysis' ,'gluconeogenesis' ,'micronucleus organization' ,'microglial cell activation' ,'positive regulation of autophagosome assembly' ,'positive regulation of NIK/NF-kappaB signaling' ,'calcium-mediated signaling' ,'positive regulation of cytokine production involved in inflammatory response' ,'cellular senescence' ,'neuron death' ,'macrophage activation' ,'cAMP biosynthetic process' ,'positive regulation of lipid catabolic process' ,'negative regulation of response to drug' ,'calcium ion import' ,'behavioral response to pain' ,'positive regulation of intracellular estrogen receptor signaling pathway' ,'regulation of bile acid metabolic process' ,'mitotic cell cycle' ,'autophagosome assembly' ,'prostaglandin metabolic process' ,'protein poly-ADP-ribosylation' ,'DNA methylation' ,'glycolytic process' ,'positive regulation of fat cell differentiation' ,'protein lipidation involved in autophagosome assembly' ,'estrogen metabolic process' ,'thyroid hormone metabolic process' ,'positive regulation of organ growth' ,'neutrophil migration' ,'NADH dehydrogenase (ubiquinone) activity' ,'prostaglandin biosynthetic process' ,'negative regulation of ATP biosynthetic process' ,'adipose tissue development' ,'larval development' ,'androgen metabolic process' ,'amino acid biosynthetic process' ,'aerobic respiration' ,'positive regulation of cellular extravasation' ,'positive regulation of neutrophil extravasation' ,'negative regulation of cell migration' ,'carbohydrate metabolic process' ,'positive regulation of JNK cascade' ,'positive regulation of neuron apoptotic process' ,'positive regulation of release of cytochrome c from mitochondria' ,'cognition' ,'vacuole organization' ,'renal sodium excretion' ,'osteoclast differentiation' ,'positive regulation of epithelial to mesenchymal transition' ,'glutathione derivative biosynthetic process' ,'arachidonic acid metabolic process' ,'neurotransmitter metabolic process' ,'stress granule assembly' ,'sperm motility' ,'hepatocyte differentiation' ,'AMP-activated protein kinase activity' ,'swimming behavior' ,'negative regulation of monooxygenase activity' ,'fatty acid homeostasis' ,'L-ascorbic acid metabolic process' ,'pyroptosis' ,'response to xenobiotic stimulus' ,'positive regulation of prostaglandin biosynthetic process' ) ) ) and ( gcr.chem_id, gcr.gene_id ) in ( select chem_id, gene_id from tetramer );

Date: 2026-03-25 16:06:10
Duration: 8s59ms
Database: ctddev51
User: pub1
Bind query: yes

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Times Reported Time consuming queries #1

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[ User: pub1 - Total duration: 8s389ms - Times executed: 1 ]

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select distinct chemTerm.acc_txt # 015, chemTerm.nm # 015, 'chemical' # 015, diseaseTerm.acc_txt # 015, diseaseTerm.nm # 015, 'disease' # 015, cdr.source_cd # 015 from pub1.CHEM_DISEASE_REFERENCE cdr # 015, pub1.TERM chemTerm # 015, pub1.TERM diseaseTerm # 015 where cdr.disease_id = diseaseTerm.id # 015 and cdr.chem_id = chemTerm.id # 015 and diseaseTerm.id in ( select descendant_object_id from pub1.DAG_PATH where ancestor_object_id = # 015 ( select id from pub1.TERM where nm = 'Amyotrophic Lateral Sclerosis' and object_type_id = 3)) # 015;

Date: 2026-03-25 16:27:26
Duration: 8s389ms
Database: ctddev51
User: pub1
Bind query: yes

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Times Reported Time consuming queries #2

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[ User: pub1 - Total duration: 8s59ms - Times executed: 1 ]

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select distinct geneTerm.acc_txt ,geneTerm.nm ,'gene' ,chemTerm.acc_txt ,chemTerm.nm ,'chemical' from pub1.GENE_CHEM_REFERENCE gcr ,pub1.TERM geneTerm ,pub1.TERM chemTerm where gcr.gene_id = geneTerm.id and gcr.chem_id = chemTerm.id and ( gcr.chem_id IN ( SELECT id FROM term WHERE nm IN ( -- genes 'NOG' ,'TNF' ,'INS' ,'CASP3' ,'IL1B' ,'IL6' ,'MAPK1' ,'NFE2L2' ,'MAPK3' ,'HMOX1' ,'AHR' ,'CYP1A1' ,'PTGS2' ,'PPARA' ,'BCL2' ,'CAT' ,'ESR1' ,'BAX' ,'NOS2' ,'RELA' ,'TGFB1' ,'TP53' ,'RORA' ,'AKT1' ,'CXCL8' ,'PPARG' ,'IFNG' ,'AR' ,'INS1' ,'ACHE' ,'PARP1' ,'CASP9' ,'CCL2' ,'NQO1' ,'CDKN1A' ,'CYP3A4' ,'MMP9' ,'SOD2' ,'APP' ,'VEGFA' ,'CYP1A2' ,'CCND1' ,'FOS' ,'NFKBIA' ,'SOD1' ,'HIF1A' ,'DDIT3' ,'ESR2' ,'JUN' ,'IL10' ,'AGT' ,'FGF2' ,'ABCB1' ,'CYP2E1' ,'GPT' ,'NR1I3' ,'CYP1B1' ,'CASP8' ,'NR1I2' ,'MAPK8' ,'EGF' ,'SIRT1' ,'GSR' ,'ACTA2' ,'MPO' ,'MYC' ,'ICAM1' ,'HSPA5' ,'MMP2' ,'G3BP1' ,'STAT3' ,'SQSTM1' ,'EGFR' ,'IL4' ,'NFKB1' ,'TLR4' ,'CASP1' ,'ALB' ,'RX3' ,'CTNNB1' ,'NOS3' ,'IGF1' ,'BCL2L1' ,'COL1A1' ,'GCLC' ,'NLRP3' ,'MAP1LC3B' ,'CDH1' ,'SREBF1' ,'GSK3B' ,'MTOR' ,'FASN' ,'PCNA' ,'ABCC2' ,'STAR' ,'PGR' ,'BDNF' ,'PPARGC1A' ,'CYP19A1' ,'GPX1' ,'H2AX' ,'LEP' ,'VIM' ,'IL18' ,'OGA' ,'GSTP1' ,'ADIPOQ' ,'BECN1' ,'IL1A' ,'TRP53' ,'FAS' ,'EGR1' ,'VCAM1' ,'NR1H4' ,'NR3C1' ,'APOE' ,'ABCG2' ,'FN1' ,'MYD88' ,'IL2' ,'CXCL1' ,'FSHB' ,'CREB1' ,'EDN1' ,'BIRC5' ,'SERPINE1' ,'ABCC1' ,'CNR1' ,'ABCB11' ,'CYCS' ,'CD36' ,'TIMP1' ,'GCLM' ,'CYP2C9' ,'TNFSF10' ,'LHB' ,'TH' ,'CXCL2' ,'FABP4' ,'BCHE' ,'ATF4' ,'PON1' ,'CYP11A1' ,'SPP1' ,'CASP7' ,'HMGCR' ,'MAPK9' ,'IL12B' ,'CYP17A1' ,'CCNB1' ,'CDKN1B' ,'CYP2B6' ,'RB1' ,'PRL' ,'MAPK14' ,'CEBPB' ,'CXCL10' ,'TIPARP' ,'GADD45A' ,'XBP1' ,'ATF3' ,'TRPV1' ,'CDK1' ,'MT1' ,'LPL' ,'GJA1' ,'MKI67' ,'MAPT' ,'ADRB2' ,'PTEN' ,'TXNRD1' ,'CPT1A' ,'KEAP1' ,'CYP7A1' ,'SLC2A1' ,'CCL5' ,'RPS6KB1' ,'ACACA' ,'KCNH2' ,'CEBPA' ,'STAT1' ,'INHBA' ,'MCL1' ,'BMP4' ,'CCN2' ,'SRC' ,'CSF2' ,'PTGS1' ,'EIF2AK3' ,'XDH' ,'SNCA' ,'ABCA1' ,'CDK2' ,'GPX4' ,'THRB' ,'CNR2' ,'DRD2' ,'LDLR' ,'GSTM1' ,'ABCC3' -- chemicals ,'bisphenol A' ,'Tetrachlorodibenzodioxin' ,'Benzo(a)pyrene' ,'Valproic Acid' ,'sodium arsenite' ,'Lipopolysaccharides' ,'Estradiol' ,'Acetaminophen' ,'4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide' ,'dorsomorphin' ,'Particulate Matter' ,'Dexamethasone' ,'Cadmium Chloride' ,'titanium dioxide' ,'Aflatoxin B1' ,'Air Pollutants' ,'Cisplatin' ,'Tobacco Smoke Pollution' ,'Carbon Tetrachloride' ,'Resveratrol' ,'Doxorubicin' ,'pirinixic acid' ,'Ethinyl Estradiol' ,'Ozone' ,'Tretinoin' ,'Ethanol' ,'Dietary Fats' ,'Thioacetamide' ,'Cyclosporine' ,'Nanotubes, Carbon' ,'perfluorooctane sulfonic acid' ,'bisphenol S' ,'Folic Acid' ,'Vehicle Emissions' ,'1,2-Dimethylhydrazine' ,'Oxygen' ,'trichostatin A' ,'1-Methyl-3-isobutylxanthine' ,'Silicon Dioxide' ,'Indomethacin' ,'bisphenol F' ,'CGP 52608' ,'Atrazine' ,'Arsenic Trioxide' ,'methylmercuric chloride' ,'Cadmium' ,'Phenobarbital' ,'arsenite' ,'decamethrin' ,'Paraquat' ,'Tetradecanoylphorbol Acetate' ,'Quercetin' ,'Propylthiouracil' ,'Hydrogen Peroxide' ,'perfluorooctanoic acid' ,'Glucose' ,'Copper' ,'Smoke' ,'Chlorpyrifos' ,'triphenyl phosphate' ,'Gentamicins' ,'Diethylhexyl Phthalate' ,'Arsenic' ,'Rotenone' ,'Diethylnitrosamine' ,'Testosterone' ,'Acrylamide' ,'Phenylmercuric Acetate' ,'Dibutyl Phthalate' ,'Streptozocin' ,'Progesterone' ,'Plant Extracts' ,'Trichloroethylene' ,'aristolochic acid I' ,'Copper Sulfate' ,'cobaltous chloride' ,'Methyl Methanesulfonate' ,'Methamphetamine' ,'(+)-JQ1 compound' ,'jinfukang' ,'deoxynivalenol' ,'vinclozolin' ,'abrine' ,'Nickel' ,'Dioxins' ,'Genistein' ,'Fulvestrant' ,'Clofibrate' ,'Rosiglitazone' ,'Soot' ,'Cocaine' ,'Sunitinib' ,'Dronabinol' ,'Methotrexate' ,'JP8 aviation fuel' ,'triptonide' ,'entinostat' ,'2,2'',4,4''-tetrabromodiphenyl ether' ,'Tamoxifen' ,'Acetylcysteine' ,'1-Methyl-4-phenylpyridinium' ,'Calcitriol' ,'Acrolein' ,'di-n-butylphosphoric acid' ,'Thiram' ,'Endosulfan' ,'Zinc' ,'Ammonium Chloride' ,'Choline' ,'Ionomycin' ,'Formaldehyde' ,'tris(1,3-dichloro-2-propyl)phosphate' ,'Caffeine' ,'potassium chromate(VI)' ,'Methionine' ,'lead acetate' ,'perfluorooctanesulfonamide' ,'lipopolysaccharide, E coli O55-B5' ,'Flutamide' ,'Vorinostat' ,'furan' ,'Ivermectin' ,'Curcumin' ,'Lead' ,'Urethane' ,'Troglitazone' ,'S-(1,2-dichlorovinyl)cysteine' ,'Fluorouracil' ,'Fenretinide' ,'ethylene dichloride' ,'Dextran Sulfate' ,'hexabromocyclododecane' ,'Asbestos, Crocidolite' ,'7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide' ,'sodium arsenate' ,'manganese chloride' ,'lipopolysaccharide, Escherichia coli O111 B4' ,'Cuprizone' ,'Methapyrilene' ,'Topotecan' ,'Isoproterenol' ,'epoxiconazole' ,'FR900359' ,'Methimazole' ,'Nicotine' ,'Antirheumatic Agents' ,'3,4,5,3'',4''-pentachlorobiphenyl' ,'methacrylaldehyde' ,'chromium hexavalent ion' ,'Triclosan' ,'Glyphosate' ,'N-Methyl-3,4-methylenedioxyamphetamine' ,'mono-(2-ethylhexyl)phthalate' ,'Aluminum' ,'Oxaliplatin' ,'T-2 Toxin' ,'Cellulose' ,'Decitabine' ,'acetamide' ,'Amitrole' ,'beta-lapachone' ,'Cyclophosphamide' ,'butyraldehyde' ,'Selenium' ,'alpha-pinene' ,'Temozolomide' ,'Amiodarone' ,'4,4''-diaminodiphenylmethane' ,'1,4-bis(2-(3,5-dichloropyridyloxy))benzene' ,'Panobinostat' ,'Diethylstilbestrol' ,'decabromobiphenyl ether' ,'Tunicamycin' ,'Carbamazepine' ,'Lactic Acid' ,'Sodium Fluoride' ,'Cannabidiol' ,'ochratoxin A' ,'epigallocatechin gallate' ,'1-Naphthylisothiocyanate' ,'fipronil' ,'Mercuric Chloride' ,'Coumestrol' ,'Paclitaxel' ,'bisphenol AF' ,'tert-Butylhydroperoxide' ,'dicrotophos' ,'sulforaphane' ,'Enzyme Inhibitors' ,'Dichlorodiphenyl Dichloroethylene' ,'1H,1H,10H,10H-perfluorodecane-1,10-diol' ,'Methoxychlor' ,'Thapsigargin' ,'Leflunomide' ,'Haloperidol' ,'2,4,5,2'',4'',5''-hexachlorobiphenyl' ,'9,10-Dimethyl-1,2-benzanthracene' ,'Silver' -- diseases ,'Chemical and Drug Induced Liver Injury' ,'Seizures' ,'Hypertension' ,'Hypotension' ,'Kidney Diseases' ,'Pain' ,'Acute Kidney Injury' ,'Breast Neoplasms' ,'Necrosis' ,'Weight Loss' ,'Inflammation' ,'Drug-Related Side Effects and Adverse Reactions' ,'Cocaine-Related Disorders' ,'Heart Failure' ,'Substance Withdrawal Syndrome' ,'Depressive Disorder' ,'Bradycardia' ,'Prostatic Neoplasms' ,'Hyperalgesia' ,'Prenatal Exposure Delayed Effects' ,'Myocardial Infarction' ,'Catalepsy' ,'Liver Cirrhosis, Experimental' ,'Hyperkinesis' ,'Edema' ,'Arrhythmias, Cardiac' ,'Carcinoma, Hepatocellular' ,'Dyskinesia, Drug-Induced' ,'Nausea' ,'Vomiting' ,'Lung Neoplasms' ,'Disease Models, Animal' ,'Hyperglycemia' ,'Hepatomegaly' ,'Weight Gain' ,'Cardiomyopathies' ,'Tachycardia' ,'Headache' ,'Bipolar Disorder' ,'Nerve Degeneration' ,'Proteinuria' ,'Diabetes Mellitus, Experimental' ,'Anemia' ,'Memory Disorders' ,'Tremor' ,'Peripheral Nervous System Diseases' ,'Fatty Liver' ,'Parkinson Disease' ,'Liver Neoplasms' ,'Status Epilepticus' ,'Schizophrenia' ,'Thrombocytopenia' ,'Liver Neoplasms, Experimental' ,'Cognition Disorders' ,'Heart Diseases' ,'Hemorrhage' ,'Arthritis, Rheumatoid' ,'Renal Insufficiency' ,'Fever' ,'Asthma' ,'Cholestasis' ,'Insulin Resistance' ,'Urinary Bladder Neoplasms' ,'Obesity' ,'Nervous System Diseases' ,'Liver Cirrhosis' ,'Poisoning' ,'Muscular Diseases' ,'Diarrhea' ,'Neoplasms, Experimental' ,'Colorectal Neoplasms' ,'Atrial Fibrillation' ,'Neutropenia' ,'Tachycardia, Ventricular' ,'Anxiety Disorders' ,'Colonic Neoplasms' ,'Epilepsy' ,'Myocardial Ischemia' ,'Stomach Neoplasms' ,'Amnesia' ,'Cardiomegaly' ,'Brain Injuries' ,'Parkinsonian Disorders' ,'Diabetes Mellitus, Type 2' ,'Neoplasm Metastasis' ,'Melanoma' ,'Neoplasm Invasiveness' ,'Torsades de Pointes' ,'Neoplasms' ,'Long QT Syndrome' ,'Ventricular Dysfunction, Left' ,'Cell Transformation, Neoplastic' ,'Thrombosis' ,'Pain, Postoperative' ,'Movement Disorders' ,'Hallucinations' ,'Dystonia' ,'Nephritis, Interstitial' ,'Stomach Ulcer' ,'Carcinoma, Non-Small-Cell Lung' ,'Pulmonary Fibrosis' ,'Brain Diseases' ,'Fibrosis' ,'Learning Disabilities' ,'Heart Arrest' ,'Drug Hypersensitivity' ,'Liver Diseases' ,'Psychoses, Substance-Induced' ,'Dizziness' ,'Cardiovascular Diseases' ,'Hypokalemia' ,'Ventricular Fibrillation' ,'Autistic Disorder' ,'Precursor Cell Lymphoblastic Leukemia-Lymphoma' ,'Myoclonus' ,'Hyperplasia' ,'Precancerous Conditions' ,'Multiple Myeloma' ,'Angina Pectoris' ,'Neurotoxicity Syndromes' ,'Liver Failure, Acute' ,'Leukemia, Promyelocytic, Acute' ,'Adenocarcinoma' ,'Basal Ganglia Diseases' ,'Cystitis' ,'Hepatitis B' ,'Hepatitis' ,'Dermatitis, Allergic Contact' ,'Leukemia, Myeloid, Acute' ,'Lung Injury' ,'HIV Infections' ,'Ataxia' ,'Ovarian Neoplasms' ,'Atherosclerosis' ,'Mammary Neoplasms, Experimental' ,'Abnormalities, Drug-Induced' ,'Confusion' ,'Staphylococcal Infections' ,'Autism Spectrum Disorder' ,'Stroke' ,'Leukopenia' ,'Testicular Diseases' ,'Reperfusion Injury' ,'Colitis' ,'Alzheimer Disease' ,'Carcinoma' ,'Glucose Intolerance' ,'Skin Neoplasms' ,'Anemia, Hemolytic' ,'Exanthema' ,'Hypertension, Pulmonary' ,'Muscle Rigidity' ,'Psychotic Disorders' ,'Hypercholesterolemia' ,'Angioedema' ,'Delirium' ,'Non-alcoholic Fatty Liver Disease' ,'Paralysis' ,'Apnea' ,'Pulmonary Edema' ,'Pneumonia' ,'Micronuclei, Chromosome-Defective' ,'Venous Thrombosis' ,'Parkinson Disease, Secondary' ,'Nephrotic Syndrome' ,'Muscle Weakness' ,'Pruritus' ,'Drug Eruptions' ,'Acute Lung Injury' ,'Hypothermia' ,'Pancreatic Neoplasms' ,'Diabetic Nephropathies' ,'Gastrointestinal Diseases' ,'Substance-Related Disorders' ,'Coma' ,'Epilepsy, Tonic-Clonic' ,'Craniofacial Abnormalities' ,'Stevens-Johnson Syndrome' ,'Migraine Disorders' ,'Vision Disorders' ,'Jaundice' ,'Paresthesia' ,'Carcinoma, Squamous Cell' ,'Fatigue' ,'Cerebral Hemorrhage' ,'Hypercalcemia' ,'Skin Diseases' ,'Hypotension, Orthostatic' ,'Urticaria' ,'Hematuria' ,'Erectile Dysfunction' ,'Colitis, Ulcerative' ,'Mammary Neoplasms, Animal' ,'Lung Diseases' ,'Rhabdomyolysis' ,'Oligospermia' ,'Depressive Disorder, Major' ,'Anemia, Aplastic' ,'Anorexia' ,'Hyperlipidemias' -- phenotypes ,'apoptotic process' ,'cell population proliferation' ,'cellular metabolic process' ,'lipid oxidation' ,'glutathione metabolic process' ,'reactive oxygen species metabolic process' ,'lipid catabolic process' ,'cell death' ,'detection of oxidative stress' ,'positive regulation of apoptotic process' ,'superoxide dismutase activity' ,'positive regulation of reactive oxygen species biosynthetic process' ,'positive regulation of cell death' ,'regulation of blood pressure' ,'reactive oxygen species biosynthetic process' ,'negative regulation of cell population proliferation' ,'regulation of mitochondrial membrane potential' ,'vasoconstriction' ,'glutathione biosynthetic process' ,'membrane lipid catabolic process' ,'glutathione peroxidase activity' ,'cellular response to DNA damage stimulus' ,'cholesterol metabolic process' ,'positive regulation of cell population proliferation' ,'triglyceride metabolic process' ,'response to oxidative stress' ,'regulation of heart rate' ,'negative regulation of mitotic cell cycle' ,'vasodilation' ,'ATP metabolic process' ,'cell growth' ,'cellular calcium ion homeostasis' ,'leukocyte migration involved in inflammatory response' ,'nitric oxide metabolic process' ,'creatinine metabolic process' ,'apoptotic DNA fragmentation' ,'lipid droplet formation' ,'ncRNA transcription' ,'protein oxidation' ,'mitotic cell cycle process' ,'DNA modification' ,'inflammatory response' ,'cholesterol homeostasis' ,'glutathione transferase activity' ,'autophagy' ,'fat cell differentiation' ,'triglyceride homeostasis' ,'lipid metabolic process' ,'necrotic cell death' ,'xenobiotic metabolic process' ,'negative regulation of superoxide dismutase activity' ,'triglyceride biosynthetic process' ,'cell migration' ,'cell redox homeostasis' ,'bile acid metabolic process' ,'nitric oxide biosynthetic process' ,'superoxide anion generation' ,'lactate dehydrogenase activity' ,'cell cycle' ,'amino acid metabolic process' ,'testosterone biosynthetic process' ,'activation of protein kinase B activity' ,'L-aspartate:2-oxoglutarate aminotransferase activity' ,'positive regulation of nitric oxide biosynthetic process' ,'cholesterol biosynthetic process' ,'protein import into nucleus' ,'positive regulation of protein import into nucleus' ,'wound healing, spreading of cells' ,'alkaline phosphatase activity' ,'positive regulation of cytosolic calcium ion concentration' ,'glucose homeostasis' ,'positive regulation of mitochondrial membrane potential' ,'fatty acid metabolic process' ,'cell chemotaxis' ,'positive regulation of vasoconstriction' ,'spermatogenesis' ,'positive regulation of neuron death' ,'positive regulation of superoxide dismutase activity' ,'collagen fibril organization' ,'cell differentiation' ,'histone H3-K9 acetylation' ,'mitochondrion organization' ,'positive regulation of protein localization to nucleus' ,'positive regulation of p38MAPK cascade' ,'ATP biosynthetic process' ,'metabolic process' ,'locomotion involved in locomotory behavior' ,'urate metabolic process' ,'dopamine metabolic process' ,'positive regulation of NF-kappaB transcription factor activity' ,'embryo development' ,'lipid biosynthetic process' ,'protein lipidation' ,'histamine secretion mediated by immunoglobulin' ,'glucose metabolic process' ,'negative regulation of mitochondrial membrane potential' ,'release of cytochrome c from mitochondria' ,'DNA catabolic process, endonucleolytic' ,'cellular respiration' ,'calcium ion homeostasis' ,'positive regulation of cell migration' ,'regulation of cellular metabolic process' ,'reactive nitrogen species metabolic process' ,'positive regulation of inflammatory response' ,'establishment of protein localization to plasma membrane' ,'lipid homeostasis' ,'response to antineoplastic agent' ,'glucose import' ,'urea metabolic process' ,'positive regulation of ERK1 and ERK2 cascade' ,'positive regulation of necrotic cell death' ,'memory' ,'negative regulation of glutathione peroxidase activity' ,'positive regulation of apoptotic DNA fragmentation' ,'mitochondrial depolarization' ,'G2/M transition of mitotic cell cycle' ,'cAMP metabolic process' ,'mitotic S phase' ,'hydrogen peroxide biosynthetic process' ,'positive regulation of superoxide anion generation' ,'positive regulation of autophagy' ,'protein modification process' ,'regulation of metabolic process' ,'cellular iron ion homeostasis' ,'lactate metabolic process' ,'DNA methylation on cytosine within a CG sequence' ,'apoptotic chromosome condensation' ,'serotonin metabolic process' ,'cellular lipid metabolic process' ,'positive regulation of glutathione peroxidase activity' ,'transepithelial transport' ,'positive regulation of lipid storage' ,'hydrogen peroxide metabolic process' ,'G0 to G1 transition' ,'positive regulation of collagen biosynthetic process' ,'iron ion homeostasis' ,'positive regulation of cytolysis' ,'gluconeogenesis' ,'micronucleus organization' ,'microglial cell activation' ,'positive regulation of autophagosome assembly' ,'positive regulation of NIK/NF-kappaB signaling' ,'calcium-mediated signaling' ,'positive regulation of cytokine production involved in inflammatory response' ,'cellular senescence' ,'neuron death' ,'macrophage activation' ,'cAMP biosynthetic process' ,'positive regulation of lipid catabolic process' ,'negative regulation of response to drug' ,'calcium ion import' ,'behavioral response to pain' ,'positive regulation of intracellular estrogen receptor signaling pathway' ,'regulation of bile acid metabolic process' ,'mitotic cell cycle' ,'autophagosome assembly' ,'prostaglandin metabolic process' ,'protein poly-ADP-ribosylation' ,'DNA methylation' ,'glycolytic process' ,'positive regulation of fat cell differentiation' ,'protein lipidation involved in autophagosome assembly' ,'estrogen metabolic process' ,'thyroid hormone metabolic process' ,'positive regulation of organ growth' ,'neutrophil migration' ,'NADH dehydrogenase (ubiquinone) activity' ,'prostaglandin biosynthetic process' ,'negative regulation of ATP biosynthetic process' ,'adipose tissue development' ,'larval development' ,'androgen metabolic process' ,'amino acid biosynthetic process' ,'aerobic respiration' ,'positive regulation of cellular extravasation' ,'positive regulation of neutrophil extravasation' ,'negative regulation of cell migration' ,'carbohydrate metabolic process' ,'positive regulation of JNK cascade' ,'positive regulation of neuron apoptotic process' ,'positive regulation of release of cytochrome c from mitochondria' ,'cognition' ,'vacuole organization' ,'renal sodium excretion' ,'osteoclast differentiation' ,'positive regulation of epithelial to mesenchymal transition' ,'glutathione derivative biosynthetic process' ,'arachidonic acid metabolic process' ,'neurotransmitter metabolic process' ,'stress granule assembly' ,'sperm motility' ,'hepatocyte differentiation' ,'AMP-activated protein kinase activity' ,'swimming behavior' ,'negative regulation of monooxygenase activity' ,'fatty acid homeostasis' ,'L-ascorbic acid metabolic process' ,'pyroptosis' ,'response to xenobiotic stimulus' ,'positive regulation of prostaglandin biosynthetic process' ) ) and gcr.gene_id IN ( SELECT id FROM term WHERE nm IN ( -- genes 'NOG' ,'TNF' ,'INS' ,'CASP3' ,'IL1B' ,'IL6' ,'MAPK1' ,'NFE2L2' ,'MAPK3' ,'HMOX1' ,'AHR' ,'CYP1A1' ,'PTGS2' ,'PPARA' ,'BCL2' ,'CAT' ,'ESR1' ,'BAX' ,'NOS2' ,'RELA' ,'TGFB1' ,'TP53' ,'RORA' ,'AKT1' ,'CXCL8' ,'PPARG' ,'IFNG' ,'AR' ,'INS1' ,'ACHE' ,'PARP1' ,'CASP9' ,'CCL2' ,'NQO1' ,'CDKN1A' ,'CYP3A4' ,'MMP9' ,'SOD2' ,'APP' ,'VEGFA' ,'CYP1A2' ,'CCND1' ,'FOS' ,'NFKBIA' ,'SOD1' ,'HIF1A' ,'DDIT3' ,'ESR2' ,'JUN' ,'IL10' ,'AGT' ,'FGF2' ,'ABCB1' ,'CYP2E1' ,'GPT' ,'NR1I3' ,'CYP1B1' ,'CASP8' ,'NR1I2' ,'MAPK8' ,'EGF' ,'SIRT1' ,'GSR' ,'ACTA2' ,'MPO' ,'MYC' ,'ICAM1' ,'HSPA5' ,'MMP2' ,'G3BP1' ,'STAT3' ,'SQSTM1' ,'EGFR' ,'IL4' ,'NFKB1' ,'TLR4' ,'CASP1' ,'ALB' ,'RX3' ,'CTNNB1' ,'NOS3' ,'IGF1' ,'BCL2L1' ,'COL1A1' ,'GCLC' ,'NLRP3' ,'MAP1LC3B' ,'CDH1' ,'SREBF1' ,'GSK3B' ,'MTOR' ,'FASN' ,'PCNA' ,'ABCC2' ,'STAR' ,'PGR' ,'BDNF' ,'PPARGC1A' ,'CYP19A1' ,'GPX1' ,'H2AX' ,'LEP' ,'VIM' ,'IL18' ,'OGA' ,'GSTP1' ,'ADIPOQ' ,'BECN1' ,'IL1A' ,'TRP53' ,'FAS' ,'EGR1' ,'VCAM1' ,'NR1H4' ,'NR3C1' ,'APOE' ,'ABCG2' ,'FN1' ,'MYD88' ,'IL2' ,'CXCL1' ,'FSHB' ,'CREB1' ,'EDN1' ,'BIRC5' ,'SERPINE1' ,'ABCC1' ,'CNR1' ,'ABCB11' ,'CYCS' ,'CD36' ,'TIMP1' ,'GCLM' ,'CYP2C9' ,'TNFSF10' ,'LHB' ,'TH' ,'CXCL2' ,'FABP4' ,'BCHE' ,'ATF4' ,'PON1' ,'CYP11A1' ,'SPP1' ,'CASP7' ,'HMGCR' ,'MAPK9' ,'IL12B' ,'CYP17A1' ,'CCNB1' ,'CDKN1B' ,'CYP2B6' ,'RB1' ,'PRL' ,'MAPK14' ,'CEBPB' ,'CXCL10' ,'TIPARP' ,'GADD45A' ,'XBP1' ,'ATF3' ,'TRPV1' ,'CDK1' ,'MT1' ,'LPL' ,'GJA1' ,'MKI67' ,'MAPT' ,'ADRB2' ,'PTEN' ,'TXNRD1' ,'CPT1A' ,'KEAP1' ,'CYP7A1' ,'SLC2A1' ,'CCL5' ,'RPS6KB1' ,'ACACA' ,'KCNH2' ,'CEBPA' ,'STAT1' ,'INHBA' ,'MCL1' ,'BMP4' ,'CCN2' ,'SRC' ,'CSF2' ,'PTGS1' ,'EIF2AK3' ,'XDH' ,'SNCA' ,'ABCA1' ,'CDK2' ,'GPX4' ,'THRB' ,'CNR2' ,'DRD2' ,'LDLR' ,'GSTM1' ,'ABCC3' -- chemicals ,'bisphenol A' ,'Tetrachlorodibenzodioxin' ,'Benzo(a)pyrene' ,'Valproic Acid' ,'sodium arsenite' ,'Lipopolysaccharides' ,'Estradiol' ,'Acetaminophen' ,'4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide' ,'dorsomorphin' ,'Particulate Matter' ,'Dexamethasone' ,'Cadmium Chloride' ,'titanium dioxide' ,'Aflatoxin B1' ,'Air Pollutants' ,'Cisplatin' ,'Tobacco Smoke Pollution' ,'Carbon Tetrachloride' ,'Resveratrol' ,'Doxorubicin' ,'pirinixic acid' ,'Ethinyl Estradiol' ,'Ozone' ,'Tretinoin' ,'Ethanol' ,'Dietary Fats' ,'Thioacetamide' ,'Cyclosporine' ,'Nanotubes, Carbon' ,'perfluorooctane sulfonic acid' ,'bisphenol S' ,'Folic Acid' ,'Vehicle Emissions' ,'1,2-Dimethylhydrazine' ,'Oxygen' ,'trichostatin A' ,'1-Methyl-3-isobutylxanthine' ,'Silicon Dioxide' ,'Indomethacin' ,'bisphenol F' ,'CGP 52608' ,'Atrazine' ,'Arsenic Trioxide' ,'methylmercuric chloride' ,'Cadmium' ,'Phenobarbital' ,'arsenite' ,'decamethrin' ,'Paraquat' ,'Tetradecanoylphorbol Acetate' ,'Quercetin' ,'Propylthiouracil' ,'Hydrogen Peroxide' ,'perfluorooctanoic acid' ,'Glucose' ,'Copper' ,'Smoke' ,'Chlorpyrifos' ,'triphenyl phosphate' ,'Gentamicins' ,'Diethylhexyl Phthalate' ,'Arsenic' ,'Rotenone' ,'Diethylnitrosamine' ,'Testosterone' ,'Acrylamide' ,'Phenylmercuric Acetate' ,'Dibutyl Phthalate' ,'Streptozocin' ,'Progesterone' ,'Plant Extracts' ,'Trichloroethylene' ,'aristolochic acid I' ,'Copper Sulfate' ,'cobaltous chloride' ,'Methyl Methanesulfonate' ,'Methamphetamine' ,'(+)-JQ1 compound' ,'jinfukang' ,'deoxynivalenol' ,'vinclozolin' ,'abrine' ,'Nickel' ,'Dioxins' ,'Genistein' ,'Fulvestrant' ,'Clofibrate' ,'Rosiglitazone' ,'Soot' ,'Cocaine' ,'Sunitinib' ,'Dronabinol' ,'Methotrexate' ,'JP8 aviation fuel' ,'triptonide' ,'entinostat' ,'2,2'',4,4''-tetrabromodiphenyl ether' ,'Tamoxifen' ,'Acetylcysteine' ,'1-Methyl-4-phenylpyridinium' ,'Calcitriol' ,'Acrolein' ,'di-n-butylphosphoric acid' ,'Thiram' ,'Endosulfan' ,'Zinc' ,'Ammonium Chloride' ,'Choline' ,'Ionomycin' ,'Formaldehyde' ,'tris(1,3-dichloro-2-propyl)phosphate' ,'Caffeine' ,'potassium chromate(VI)' ,'Methionine' ,'lead acetate' ,'perfluorooctanesulfonamide' ,'lipopolysaccharide, E coli O55-B5' ,'Flutamide' ,'Vorinostat' ,'furan' ,'Ivermectin' ,'Curcumin' ,'Lead' ,'Urethane' ,'Troglitazone' ,'S-(1,2-dichlorovinyl)cysteine' ,'Fluorouracil' ,'Fenretinide' ,'ethylene dichloride' ,'Dextran Sulfate' ,'hexabromocyclododecane' ,'Asbestos, Crocidolite' ,'7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide' ,'sodium arsenate' ,'manganese chloride' ,'lipopolysaccharide, Escherichia coli O111 B4' ,'Cuprizone' ,'Methapyrilene' ,'Topotecan' ,'Isoproterenol' ,'epoxiconazole' ,'FR900359' ,'Methimazole' ,'Nicotine' ,'Antirheumatic Agents' ,'3,4,5,3'',4''-pentachlorobiphenyl' ,'methacrylaldehyde' ,'chromium hexavalent ion' ,'Triclosan' ,'Glyphosate' ,'N-Methyl-3,4-methylenedioxyamphetamine' ,'mono-(2-ethylhexyl)phthalate' ,'Aluminum' ,'Oxaliplatin' ,'T-2 Toxin' ,'Cellulose' ,'Decitabine' ,'acetamide' ,'Amitrole' ,'beta-lapachone' ,'Cyclophosphamide' ,'butyraldehyde' ,'Selenium' ,'alpha-pinene' ,'Temozolomide' ,'Amiodarone' ,'4,4''-diaminodiphenylmethane' ,'1,4-bis(2-(3,5-dichloropyridyloxy))benzene' ,'Panobinostat' ,'Diethylstilbestrol' ,'decabromobiphenyl ether' ,'Tunicamycin' ,'Carbamazepine' ,'Lactic Acid' ,'Sodium Fluoride' ,'Cannabidiol' ,'ochratoxin A' ,'epigallocatechin gallate' ,'1-Naphthylisothiocyanate' ,'fipronil' ,'Mercuric Chloride' ,'Coumestrol' ,'Paclitaxel' ,'bisphenol AF' ,'tert-Butylhydroperoxide' ,'dicrotophos' ,'sulforaphane' ,'Enzyme Inhibitors' ,'Dichlorodiphenyl Dichloroethylene' ,'1H,1H,10H,10H-perfluorodecane-1,10-diol' ,'Methoxychlor' ,'Thapsigargin' ,'Leflunomide' ,'Haloperidol' ,'2,4,5,2'',4'',5''-hexachlorobiphenyl' ,'9,10-Dimethyl-1,2-benzanthracene' ,'Silver' -- diseases ,'Chemical and Drug Induced Liver Injury' ,'Seizures' ,'Hypertension' ,'Hypotension' ,'Kidney Diseases' ,'Pain' ,'Acute Kidney Injury' ,'Breast Neoplasms' ,'Necrosis' ,'Weight Loss' ,'Inflammation' ,'Drug-Related Side Effects and Adverse Reactions' ,'Cocaine-Related Disorders' ,'Heart Failure' ,'Substance Withdrawal Syndrome' ,'Depressive Disorder' ,'Bradycardia' ,'Prostatic Neoplasms' ,'Hyperalgesia' ,'Prenatal Exposure Delayed Effects' ,'Myocardial Infarction' ,'Catalepsy' ,'Liver Cirrhosis, Experimental' ,'Hyperkinesis' ,'Edema' ,'Arrhythmias, Cardiac' ,'Carcinoma, Hepatocellular' ,'Dyskinesia, Drug-Induced' ,'Nausea' ,'Vomiting' ,'Lung Neoplasms' ,'Disease Models, Animal' ,'Hyperglycemia' ,'Hepatomegaly' ,'Weight Gain' ,'Cardiomyopathies' ,'Tachycardia' ,'Headache' ,'Bipolar Disorder' ,'Nerve Degeneration' ,'Proteinuria' ,'Diabetes Mellitus, Experimental' ,'Anemia' ,'Memory Disorders' ,'Tremor' ,'Peripheral Nervous System Diseases' ,'Fatty Liver' ,'Parkinson Disease' ,'Liver Neoplasms' ,'Status Epilepticus' ,'Schizophrenia' ,'Thrombocytopenia' ,'Liver Neoplasms, Experimental' ,'Cognition Disorders' ,'Heart Diseases' ,'Hemorrhage' ,'Arthritis, Rheumatoid' ,'Renal Insufficiency' ,'Fever' ,'Asthma' ,'Cholestasis' ,'Insulin Resistance' ,'Urinary Bladder Neoplasms' ,'Obesity' ,'Nervous System Diseases' ,'Liver Cirrhosis' ,'Poisoning' ,'Muscular Diseases' ,'Diarrhea' ,'Neoplasms, Experimental' ,'Colorectal Neoplasms' ,'Atrial Fibrillation' ,'Neutropenia' ,'Tachycardia, Ventricular' ,'Anxiety Disorders' ,'Colonic Neoplasms' ,'Epilepsy' ,'Myocardial Ischemia' ,'Stomach Neoplasms' ,'Amnesia' ,'Cardiomegaly' ,'Brain Injuries' ,'Parkinsonian Disorders' ,'Diabetes Mellitus, Type 2' ,'Neoplasm Metastasis' ,'Melanoma' ,'Neoplasm Invasiveness' ,'Torsades de Pointes' ,'Neoplasms' ,'Long QT Syndrome' ,'Ventricular Dysfunction, Left' ,'Cell Transformation, Neoplastic' ,'Thrombosis' ,'Pain, Postoperative' ,'Movement Disorders' ,'Hallucinations' ,'Dystonia' ,'Nephritis, Interstitial' ,'Stomach Ulcer' ,'Carcinoma, Non-Small-Cell Lung' ,'Pulmonary Fibrosis' ,'Brain Diseases' ,'Fibrosis' ,'Learning Disabilities' ,'Heart Arrest' ,'Drug Hypersensitivity' ,'Liver Diseases' ,'Psychoses, Substance-Induced' ,'Dizziness' ,'Cardiovascular Diseases' ,'Hypokalemia' ,'Ventricular Fibrillation' ,'Autistic Disorder' ,'Precursor Cell Lymphoblastic Leukemia-Lymphoma' ,'Myoclonus' ,'Hyperplasia' ,'Precancerous Conditions' ,'Multiple Myeloma' ,'Angina Pectoris' ,'Neurotoxicity Syndromes' ,'Liver Failure, Acute' ,'Leukemia, Promyelocytic, Acute' ,'Adenocarcinoma' ,'Basal Ganglia Diseases' ,'Cystitis' ,'Hepatitis B' ,'Hepatitis' ,'Dermatitis, Allergic Contact' ,'Leukemia, Myeloid, Acute' ,'Lung Injury' ,'HIV Infections' ,'Ataxia' ,'Ovarian Neoplasms' ,'Atherosclerosis' ,'Mammary Neoplasms, Experimental' ,'Abnormalities, Drug-Induced' ,'Confusion' ,'Staphylococcal Infections' ,'Autism Spectrum Disorder' ,'Stroke' ,'Leukopenia' ,'Testicular Diseases' ,'Reperfusion Injury' ,'Colitis' ,'Alzheimer Disease' ,'Carcinoma' ,'Glucose Intolerance' ,'Skin Neoplasms' ,'Anemia, Hemolytic' ,'Exanthema' ,'Hypertension, Pulmonary' ,'Muscle Rigidity' ,'Psychotic Disorders' ,'Hypercholesterolemia' ,'Angioedema' ,'Delirium' ,'Non-alcoholic Fatty Liver Disease' ,'Paralysis' ,'Apnea' ,'Pulmonary Edema' ,'Pneumonia' ,'Micronuclei, Chromosome-Defective' ,'Venous Thrombosis' ,'Parkinson Disease, Secondary' ,'Nephrotic Syndrome' ,'Muscle Weakness' ,'Pruritus' ,'Drug Eruptions' ,'Acute Lung Injury' ,'Hypothermia' ,'Pancreatic Neoplasms' ,'Diabetic Nephropathies' ,'Gastrointestinal Diseases' ,'Substance-Related Disorders' ,'Coma' ,'Epilepsy, Tonic-Clonic' ,'Craniofacial Abnormalities' ,'Stevens-Johnson Syndrome' ,'Migraine Disorders' ,'Vision Disorders' ,'Jaundice' ,'Paresthesia' ,'Carcinoma, Squamous Cell' ,'Fatigue' ,'Cerebral Hemorrhage' ,'Hypercalcemia' ,'Skin Diseases' ,'Hypotension, Orthostatic' ,'Urticaria' ,'Hematuria' ,'Erectile Dysfunction' ,'Colitis, Ulcerative' ,'Mammary Neoplasms, Animal' ,'Lung Diseases' ,'Rhabdomyolysis' ,'Oligospermia' ,'Depressive Disorder, Major' ,'Anemia, Aplastic' ,'Anorexia' ,'Hyperlipidemias' -- phenotypes ,'apoptotic process' ,'cell population proliferation' ,'cellular metabolic process' ,'lipid oxidation' ,'glutathione metabolic process' ,'reactive oxygen species metabolic process' ,'lipid catabolic process' ,'cell death' ,'detection of oxidative stress' ,'positive regulation of apoptotic process' ,'superoxide dismutase activity' ,'positive regulation of reactive oxygen species biosynthetic process' ,'positive regulation of cell death' ,'regulation of blood pressure' ,'reactive oxygen species biosynthetic process' ,'negative regulation of cell population proliferation' ,'regulation of mitochondrial membrane potential' ,'vasoconstriction' ,'glutathione biosynthetic process' ,'membrane lipid catabolic process' ,'glutathione peroxidase activity' ,'cellular response to DNA damage stimulus' ,'cholesterol metabolic process' ,'positive regulation of cell population proliferation' ,'triglyceride metabolic process' ,'response to oxidative stress' ,'regulation of heart rate' ,'negative regulation of mitotic cell cycle' ,'vasodilation' ,'ATP metabolic process' ,'cell growth' ,'cellular calcium ion homeostasis' ,'leukocyte migration involved in inflammatory response' ,'nitric oxide metabolic process' ,'creatinine metabolic process' ,'apoptotic DNA fragmentation' ,'lipid droplet formation' ,'ncRNA transcription' ,'protein oxidation' ,'mitotic cell cycle process' ,'DNA modification' ,'inflammatory response' ,'cholesterol homeostasis' ,'glutathione transferase activity' ,'autophagy' ,'fat cell differentiation' ,'triglyceride homeostasis' ,'lipid metabolic process' ,'necrotic cell death' ,'xenobiotic metabolic process' ,'negative regulation of superoxide dismutase activity' ,'triglyceride biosynthetic process' ,'cell migration' ,'cell redox homeostasis' ,'bile acid metabolic process' ,'nitric oxide biosynthetic process' ,'superoxide anion generation' ,'lactate dehydrogenase activity' ,'cell cycle' ,'amino acid metabolic process' ,'testosterone biosynthetic process' ,'activation of protein kinase B activity' ,'L-aspartate:2-oxoglutarate aminotransferase activity' ,'positive regulation of nitric oxide biosynthetic process' ,'cholesterol biosynthetic process' ,'protein import into nucleus' ,'positive regulation of protein import into nucleus' ,'wound healing, spreading of cells' ,'alkaline phosphatase activity' ,'positive regulation of cytosolic calcium ion concentration' ,'glucose homeostasis' ,'positive regulation of mitochondrial membrane potential' ,'fatty acid metabolic process' ,'cell chemotaxis' ,'positive regulation of vasoconstriction' ,'spermatogenesis' ,'positive regulation of neuron death' ,'positive regulation of superoxide dismutase activity' ,'collagen fibril organization' ,'cell differentiation' ,'histone H3-K9 acetylation' ,'mitochondrion organization' ,'positive regulation of protein localization to nucleus' ,'positive regulation of p38MAPK cascade' ,'ATP biosynthetic process' ,'metabolic process' ,'locomotion involved in locomotory behavior' ,'urate metabolic process' ,'dopamine metabolic process' ,'positive regulation of NF-kappaB transcription factor activity' ,'embryo development' ,'lipid biosynthetic process' ,'protein lipidation' ,'histamine secretion mediated by immunoglobulin' ,'glucose metabolic process' ,'negative regulation of mitochondrial membrane potential' ,'release of cytochrome c from mitochondria' ,'DNA catabolic process, endonucleolytic' ,'cellular respiration' ,'calcium ion homeostasis' ,'positive regulation of cell migration' ,'regulation of cellular metabolic process' ,'reactive nitrogen species metabolic process' ,'positive regulation of inflammatory response' ,'establishment of protein localization to plasma membrane' ,'lipid homeostasis' ,'response to antineoplastic agent' ,'glucose import' ,'urea metabolic process' ,'positive regulation of ERK1 and ERK2 cascade' ,'positive regulation of necrotic cell death' ,'memory' ,'negative regulation of glutathione peroxidase activity' ,'positive regulation of apoptotic DNA fragmentation' ,'mitochondrial depolarization' ,'G2/M transition of mitotic cell cycle' ,'cAMP metabolic process' ,'mitotic S phase' ,'hydrogen peroxide biosynthetic process' ,'positive regulation of superoxide anion generation' ,'positive regulation of autophagy' ,'protein modification process' ,'regulation of metabolic process' ,'cellular iron ion homeostasis' ,'lactate metabolic process' ,'DNA methylation on cytosine within a CG sequence' ,'apoptotic chromosome condensation' ,'serotonin metabolic process' ,'cellular lipid metabolic process' ,'positive regulation of glutathione peroxidase activity' ,'transepithelial transport' ,'positive regulation of lipid storage' ,'hydrogen peroxide metabolic process' ,'G0 to G1 transition' ,'positive regulation of collagen biosynthetic process' ,'iron ion homeostasis' ,'positive regulation of cytolysis' ,'gluconeogenesis' ,'micronucleus organization' ,'microglial cell activation' ,'positive regulation of autophagosome assembly' ,'positive regulation of NIK/NF-kappaB signaling' ,'calcium-mediated signaling' ,'positive regulation of cytokine production involved in inflammatory response' ,'cellular senescence' ,'neuron death' ,'macrophage activation' ,'cAMP biosynthetic process' ,'positive regulation of lipid catabolic process' ,'negative regulation of response to drug' ,'calcium ion import' ,'behavioral response to pain' ,'positive regulation of intracellular estrogen receptor signaling pathway' ,'regulation of bile acid metabolic process' ,'mitotic cell cycle' ,'autophagosome assembly' ,'prostaglandin metabolic process' ,'protein poly-ADP-ribosylation' ,'DNA methylation' ,'glycolytic process' ,'positive regulation of fat cell differentiation' ,'protein lipidation involved in autophagosome assembly' ,'estrogen metabolic process' ,'thyroid hormone metabolic process' ,'positive regulation of organ growth' ,'neutrophil migration' ,'NADH dehydrogenase (ubiquinone) activity' ,'prostaglandin biosynthetic process' ,'negative regulation of ATP biosynthetic process' ,'adipose tissue development' ,'larval development' ,'androgen metabolic process' ,'amino acid biosynthetic process' ,'aerobic respiration' ,'positive regulation of cellular extravasation' ,'positive regulation of neutrophil extravasation' ,'negative regulation of cell migration' ,'carbohydrate metabolic process' ,'positive regulation of JNK cascade' ,'positive regulation of neuron apoptotic process' ,'positive regulation of release of cytochrome c from mitochondria' ,'cognition' ,'vacuole organization' ,'renal sodium excretion' ,'osteoclast differentiation' ,'positive regulation of epithelial to mesenchymal transition' ,'glutathione derivative biosynthetic process' ,'arachidonic acid metabolic process' ,'neurotransmitter metabolic process' ,'stress granule assembly' ,'sperm motility' ,'hepatocyte differentiation' ,'AMP-activated protein kinase activity' ,'swimming behavior' ,'negative regulation of monooxygenase activity' ,'fatty acid homeostasis' ,'L-ascorbic acid metabolic process' ,'pyroptosis' ,'response to xenobiotic stimulus' ,'positive regulation of prostaglandin biosynthetic process' ) ) ) and ( gcr.chem_id, gcr.gene_id ) in ( select chem_id, gene_id from tetramer );

Date: 2026-03-25 16:06:10
Duration: 8s59ms
Database: ctddev51
User: pub1
Bind query: yes

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Times Reported Time consuming queries #1

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[ User: pub1 - Total duration: 8s389ms - Times executed: 1 ]

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select distinct chemTerm.acc_txt # 015, chemTerm.nm # 015, 'chemical' # 015, diseaseTerm.acc_txt # 015, diseaseTerm.nm # 015, 'disease' # 015, cdr.source_cd # 015 from pub1.CHEM_DISEASE_REFERENCE cdr # 015, pub1.TERM chemTerm # 015, pub1.TERM diseaseTerm # 015 where cdr.disease_id = diseaseTerm.id # 015 and cdr.chem_id = chemTerm.id # 015 and diseaseTerm.id in ( select descendant_object_id from pub1.DAG_PATH where ancestor_object_id = # 015 ( select id from pub1.TERM where nm = 'Amyotrophic Lateral Sclerosis' and object_type_id = 3)) # 015;

Date: 2026-03-25 16:27:26
Duration: 8s389ms
Database: ctddev51
User: pub1
Bind query: yes

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Times Reported Time consuming queries #2

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[ User: pub1 - Total duration: 8s59ms - Times executed: 1 ]

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select distinct geneTerm.acc_txt ,geneTerm.nm ,'gene' ,chemTerm.acc_txt ,chemTerm.nm ,'chemical' from pub1.GENE_CHEM_REFERENCE gcr ,pub1.TERM geneTerm ,pub1.TERM chemTerm where gcr.gene_id = geneTerm.id and gcr.chem_id = chemTerm.id and ( gcr.chem_id IN ( SELECT id FROM term WHERE nm IN ( -- genes 'NOG' ,'TNF' ,'INS' ,'CASP3' ,'IL1B' ,'IL6' ,'MAPK1' ,'NFE2L2' ,'MAPK3' ,'HMOX1' ,'AHR' ,'CYP1A1' ,'PTGS2' ,'PPARA' ,'BCL2' ,'CAT' ,'ESR1' ,'BAX' ,'NOS2' ,'RELA' ,'TGFB1' ,'TP53' ,'RORA' ,'AKT1' ,'CXCL8' ,'PPARG' ,'IFNG' ,'AR' ,'INS1' ,'ACHE' ,'PARP1' ,'CASP9' ,'CCL2' ,'NQO1' ,'CDKN1A' ,'CYP3A4' ,'MMP9' ,'SOD2' ,'APP' ,'VEGFA' ,'CYP1A2' ,'CCND1' ,'FOS' ,'NFKBIA' ,'SOD1' ,'HIF1A' ,'DDIT3' ,'ESR2' ,'JUN' ,'IL10' ,'AGT' ,'FGF2' ,'ABCB1' ,'CYP2E1' ,'GPT' ,'NR1I3' ,'CYP1B1' ,'CASP8' ,'NR1I2' ,'MAPK8' ,'EGF' ,'SIRT1' ,'GSR' ,'ACTA2' ,'MPO' ,'MYC' ,'ICAM1' ,'HSPA5' ,'MMP2' ,'G3BP1' ,'STAT3' ,'SQSTM1' ,'EGFR' ,'IL4' ,'NFKB1' ,'TLR4' ,'CASP1' ,'ALB' ,'RX3' ,'CTNNB1' ,'NOS3' ,'IGF1' ,'BCL2L1' ,'COL1A1' ,'GCLC' ,'NLRP3' ,'MAP1LC3B' ,'CDH1' ,'SREBF1' ,'GSK3B' ,'MTOR' ,'FASN' ,'PCNA' ,'ABCC2' ,'STAR' ,'PGR' ,'BDNF' ,'PPARGC1A' ,'CYP19A1' ,'GPX1' ,'H2AX' ,'LEP' ,'VIM' ,'IL18' ,'OGA' ,'GSTP1' ,'ADIPOQ' ,'BECN1' ,'IL1A' ,'TRP53' ,'FAS' ,'EGR1' ,'VCAM1' ,'NR1H4' ,'NR3C1' ,'APOE' ,'ABCG2' ,'FN1' ,'MYD88' ,'IL2' ,'CXCL1' ,'FSHB' ,'CREB1' ,'EDN1' ,'BIRC5' ,'SERPINE1' ,'ABCC1' ,'CNR1' ,'ABCB11' ,'CYCS' ,'CD36' ,'TIMP1' ,'GCLM' ,'CYP2C9' ,'TNFSF10' ,'LHB' ,'TH' ,'CXCL2' ,'FABP4' ,'BCHE' ,'ATF4' ,'PON1' ,'CYP11A1' ,'SPP1' ,'CASP7' ,'HMGCR' ,'MAPK9' ,'IL12B' ,'CYP17A1' ,'CCNB1' ,'CDKN1B' ,'CYP2B6' ,'RB1' ,'PRL' ,'MAPK14' ,'CEBPB' ,'CXCL10' ,'TIPARP' ,'GADD45A' ,'XBP1' ,'ATF3' ,'TRPV1' ,'CDK1' ,'MT1' ,'LPL' ,'GJA1' ,'MKI67' ,'MAPT' ,'ADRB2' ,'PTEN' ,'TXNRD1' ,'CPT1A' ,'KEAP1' ,'CYP7A1' ,'SLC2A1' ,'CCL5' ,'RPS6KB1' ,'ACACA' ,'KCNH2' ,'CEBPA' ,'STAT1' ,'INHBA' ,'MCL1' ,'BMP4' ,'CCN2' ,'SRC' ,'CSF2' ,'PTGS1' ,'EIF2AK3' ,'XDH' ,'SNCA' ,'ABCA1' ,'CDK2' ,'GPX4' ,'THRB' ,'CNR2' ,'DRD2' ,'LDLR' ,'GSTM1' ,'ABCC3' -- chemicals ,'bisphenol A' ,'Tetrachlorodibenzodioxin' ,'Benzo(a)pyrene' ,'Valproic Acid' ,'sodium arsenite' ,'Lipopolysaccharides' ,'Estradiol' ,'Acetaminophen' ,'4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide' ,'dorsomorphin' ,'Particulate Matter' ,'Dexamethasone' ,'Cadmium Chloride' ,'titanium dioxide' ,'Aflatoxin B1' ,'Air Pollutants' ,'Cisplatin' ,'Tobacco Smoke Pollution' ,'Carbon Tetrachloride' ,'Resveratrol' ,'Doxorubicin' ,'pirinixic acid' ,'Ethinyl Estradiol' ,'Ozone' ,'Tretinoin' ,'Ethanol' ,'Dietary Fats' ,'Thioacetamide' ,'Cyclosporine' ,'Nanotubes, Carbon' ,'perfluorooctane sulfonic acid' ,'bisphenol S' ,'Folic Acid' ,'Vehicle Emissions' ,'1,2-Dimethylhydrazine' ,'Oxygen' ,'trichostatin A' ,'1-Methyl-3-isobutylxanthine' ,'Silicon Dioxide' ,'Indomethacin' ,'bisphenol F' ,'CGP 52608' ,'Atrazine' ,'Arsenic Trioxide' ,'methylmercuric chloride' ,'Cadmium' ,'Phenobarbital' ,'arsenite' ,'decamethrin' ,'Paraquat' ,'Tetradecanoylphorbol Acetate' ,'Quercetin' ,'Propylthiouracil' ,'Hydrogen Peroxide' ,'perfluorooctanoic acid' ,'Glucose' ,'Copper' ,'Smoke' ,'Chlorpyrifos' ,'triphenyl phosphate' ,'Gentamicins' ,'Diethylhexyl Phthalate' ,'Arsenic' ,'Rotenone' ,'Diethylnitrosamine' ,'Testosterone' ,'Acrylamide' ,'Phenylmercuric Acetate' ,'Dibutyl Phthalate' ,'Streptozocin' ,'Progesterone' ,'Plant Extracts' ,'Trichloroethylene' ,'aristolochic acid I' ,'Copper Sulfate' ,'cobaltous chloride' ,'Methyl Methanesulfonate' ,'Methamphetamine' ,'(+)-JQ1 compound' ,'jinfukang' ,'deoxynivalenol' ,'vinclozolin' ,'abrine' ,'Nickel' ,'Dioxins' ,'Genistein' ,'Fulvestrant' ,'Clofibrate' ,'Rosiglitazone' ,'Soot' ,'Cocaine' ,'Sunitinib' ,'Dronabinol' ,'Methotrexate' ,'JP8 aviation fuel' ,'triptonide' ,'entinostat' ,'2,2'',4,4''-tetrabromodiphenyl ether' ,'Tamoxifen' ,'Acetylcysteine' ,'1-Methyl-4-phenylpyridinium' ,'Calcitriol' ,'Acrolein' ,'di-n-butylphosphoric acid' ,'Thiram' ,'Endosulfan' ,'Zinc' ,'Ammonium Chloride' ,'Choline' ,'Ionomycin' ,'Formaldehyde' ,'tris(1,3-dichloro-2-propyl)phosphate' ,'Caffeine' ,'potassium chromate(VI)' ,'Methionine' ,'lead acetate' ,'perfluorooctanesulfonamide' ,'lipopolysaccharide, E coli O55-B5' ,'Flutamide' ,'Vorinostat' ,'furan' ,'Ivermectin' ,'Curcumin' ,'Lead' ,'Urethane' ,'Troglitazone' ,'S-(1,2-dichlorovinyl)cysteine' ,'Fluorouracil' ,'Fenretinide' ,'ethylene dichloride' ,'Dextran Sulfate' ,'hexabromocyclododecane' ,'Asbestos, Crocidolite' ,'7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide' ,'sodium arsenate' ,'manganese chloride' ,'lipopolysaccharide, Escherichia coli O111 B4' ,'Cuprizone' ,'Methapyrilene' ,'Topotecan' ,'Isoproterenol' ,'epoxiconazole' ,'FR900359' ,'Methimazole' ,'Nicotine' ,'Antirheumatic Agents' ,'3,4,5,3'',4''-pentachlorobiphenyl' ,'methacrylaldehyde' ,'chromium hexavalent ion' ,'Triclosan' ,'Glyphosate' ,'N-Methyl-3,4-methylenedioxyamphetamine' ,'mono-(2-ethylhexyl)phthalate' ,'Aluminum' ,'Oxaliplatin' ,'T-2 Toxin' ,'Cellulose' ,'Decitabine' ,'acetamide' ,'Amitrole' ,'beta-lapachone' ,'Cyclophosphamide' ,'butyraldehyde' ,'Selenium' ,'alpha-pinene' ,'Temozolomide' ,'Amiodarone' ,'4,4''-diaminodiphenylmethane' ,'1,4-bis(2-(3,5-dichloropyridyloxy))benzene' ,'Panobinostat' ,'Diethylstilbestrol' ,'decabromobiphenyl ether' ,'Tunicamycin' ,'Carbamazepine' ,'Lactic Acid' ,'Sodium Fluoride' ,'Cannabidiol' ,'ochratoxin A' ,'epigallocatechin gallate' ,'1-Naphthylisothiocyanate' ,'fipronil' ,'Mercuric Chloride' ,'Coumestrol' ,'Paclitaxel' ,'bisphenol AF' ,'tert-Butylhydroperoxide' ,'dicrotophos' ,'sulforaphane' ,'Enzyme Inhibitors' ,'Dichlorodiphenyl Dichloroethylene' ,'1H,1H,10H,10H-perfluorodecane-1,10-diol' ,'Methoxychlor' ,'Thapsigargin' ,'Leflunomide' ,'Haloperidol' ,'2,4,5,2'',4'',5''-hexachlorobiphenyl' ,'9,10-Dimethyl-1,2-benzanthracene' ,'Silver' -- diseases ,'Chemical and Drug Induced Liver Injury' ,'Seizures' ,'Hypertension' ,'Hypotension' ,'Kidney Diseases' ,'Pain' ,'Acute Kidney Injury' ,'Breast Neoplasms' ,'Necrosis' ,'Weight Loss' ,'Inflammation' ,'Drug-Related Side Effects and Adverse Reactions' ,'Cocaine-Related Disorders' ,'Heart Failure' ,'Substance Withdrawal Syndrome' ,'Depressive Disorder' ,'Bradycardia' ,'Prostatic Neoplasms' ,'Hyperalgesia' ,'Prenatal Exposure Delayed Effects' ,'Myocardial Infarction' ,'Catalepsy' ,'Liver Cirrhosis, Experimental' ,'Hyperkinesis' ,'Edema' ,'Arrhythmias, Cardiac' ,'Carcinoma, Hepatocellular' ,'Dyskinesia, Drug-Induced' ,'Nausea' ,'Vomiting' ,'Lung Neoplasms' ,'Disease Models, Animal' ,'Hyperglycemia' ,'Hepatomegaly' ,'Weight Gain' ,'Cardiomyopathies' ,'Tachycardia' ,'Headache' ,'Bipolar Disorder' ,'Nerve Degeneration' ,'Proteinuria' ,'Diabetes Mellitus, Experimental' ,'Anemia' ,'Memory Disorders' ,'Tremor' ,'Peripheral Nervous System Diseases' ,'Fatty Liver' ,'Parkinson Disease' ,'Liver Neoplasms' ,'Status Epilepticus' ,'Schizophrenia' ,'Thrombocytopenia' ,'Liver Neoplasms, Experimental' ,'Cognition Disorders' ,'Heart Diseases' ,'Hemorrhage' ,'Arthritis, Rheumatoid' ,'Renal Insufficiency' ,'Fever' ,'Asthma' ,'Cholestasis' ,'Insulin Resistance' ,'Urinary Bladder Neoplasms' ,'Obesity' ,'Nervous System Diseases' ,'Liver Cirrhosis' ,'Poisoning' ,'Muscular Diseases' ,'Diarrhea' ,'Neoplasms, Experimental' ,'Colorectal Neoplasms' ,'Atrial Fibrillation' ,'Neutropenia' ,'Tachycardia, Ventricular' ,'Anxiety Disorders' ,'Colonic Neoplasms' ,'Epilepsy' ,'Myocardial Ischemia' ,'Stomach Neoplasms' ,'Amnesia' ,'Cardiomegaly' ,'Brain Injuries' ,'Parkinsonian Disorders' ,'Diabetes Mellitus, Type 2' ,'Neoplasm Metastasis' ,'Melanoma' ,'Neoplasm Invasiveness' ,'Torsades de Pointes' ,'Neoplasms' ,'Long QT Syndrome' ,'Ventricular Dysfunction, Left' ,'Cell Transformation, Neoplastic' ,'Thrombosis' ,'Pain, Postoperative' ,'Movement Disorders' ,'Hallucinations' ,'Dystonia' ,'Nephritis, Interstitial' ,'Stomach Ulcer' ,'Carcinoma, Non-Small-Cell Lung' ,'Pulmonary Fibrosis' ,'Brain Diseases' ,'Fibrosis' ,'Learning Disabilities' ,'Heart Arrest' ,'Drug Hypersensitivity' ,'Liver Diseases' ,'Psychoses, Substance-Induced' ,'Dizziness' ,'Cardiovascular Diseases' ,'Hypokalemia' ,'Ventricular Fibrillation' ,'Autistic Disorder' ,'Precursor Cell Lymphoblastic Leukemia-Lymphoma' ,'Myoclonus' ,'Hyperplasia' ,'Precancerous Conditions' ,'Multiple Myeloma' ,'Angina Pectoris' ,'Neurotoxicity Syndromes' ,'Liver Failure, Acute' ,'Leukemia, Promyelocytic, Acute' ,'Adenocarcinoma' ,'Basal Ganglia Diseases' ,'Cystitis' ,'Hepatitis B' ,'Hepatitis' ,'Dermatitis, Allergic Contact' ,'Leukemia, Myeloid, Acute' ,'Lung Injury' ,'HIV Infections' ,'Ataxia' ,'Ovarian Neoplasms' ,'Atherosclerosis' ,'Mammary Neoplasms, Experimental' ,'Abnormalities, Drug-Induced' ,'Confusion' ,'Staphylococcal Infections' ,'Autism Spectrum Disorder' ,'Stroke' ,'Leukopenia' ,'Testicular Diseases' ,'Reperfusion Injury' ,'Colitis' ,'Alzheimer Disease' ,'Carcinoma' ,'Glucose Intolerance' ,'Skin Neoplasms' ,'Anemia, Hemolytic' ,'Exanthema' ,'Hypertension, Pulmonary' ,'Muscle Rigidity' ,'Psychotic Disorders' ,'Hypercholesterolemia' ,'Angioedema' ,'Delirium' ,'Non-alcoholic Fatty Liver Disease' ,'Paralysis' ,'Apnea' ,'Pulmonary Edema' ,'Pneumonia' ,'Micronuclei, Chromosome-Defective' ,'Venous Thrombosis' ,'Parkinson Disease, Secondary' ,'Nephrotic Syndrome' ,'Muscle Weakness' ,'Pruritus' ,'Drug Eruptions' ,'Acute Lung Injury' ,'Hypothermia' ,'Pancreatic Neoplasms' ,'Diabetic Nephropathies' ,'Gastrointestinal Diseases' ,'Substance-Related Disorders' ,'Coma' ,'Epilepsy, Tonic-Clonic' ,'Craniofacial Abnormalities' ,'Stevens-Johnson Syndrome' ,'Migraine Disorders' ,'Vision Disorders' ,'Jaundice' ,'Paresthesia' ,'Carcinoma, Squamous Cell' ,'Fatigue' ,'Cerebral Hemorrhage' ,'Hypercalcemia' ,'Skin Diseases' ,'Hypotension, Orthostatic' ,'Urticaria' ,'Hematuria' ,'Erectile Dysfunction' ,'Colitis, Ulcerative' ,'Mammary Neoplasms, Animal' ,'Lung Diseases' ,'Rhabdomyolysis' ,'Oligospermia' ,'Depressive Disorder, Major' ,'Anemia, Aplastic' ,'Anorexia' ,'Hyperlipidemias' -- phenotypes ,'apoptotic process' ,'cell population proliferation' ,'cellular metabolic process' ,'lipid oxidation' ,'glutathione metabolic process' ,'reactive oxygen species metabolic process' ,'lipid catabolic process' ,'cell death' ,'detection of oxidative stress' ,'positive regulation of apoptotic process' ,'superoxide dismutase activity' ,'positive regulation of reactive oxygen species biosynthetic process' ,'positive regulation of cell death' ,'regulation of blood pressure' ,'reactive oxygen species biosynthetic process' ,'negative regulation of cell population proliferation' ,'regulation of mitochondrial membrane potential' ,'vasoconstriction' ,'glutathione biosynthetic process' ,'membrane lipid catabolic process' ,'glutathione peroxidase activity' ,'cellular response to DNA damage stimulus' ,'cholesterol metabolic process' ,'positive regulation of cell population proliferation' ,'triglyceride metabolic process' ,'response to oxidative stress' ,'regulation of heart rate' ,'negative regulation of mitotic cell cycle' ,'vasodilation' ,'ATP metabolic process' ,'cell growth' ,'cellular calcium ion homeostasis' ,'leukocyte migration involved in inflammatory response' ,'nitric oxide metabolic process' ,'creatinine metabolic process' ,'apoptotic DNA fragmentation' ,'lipid droplet formation' ,'ncRNA transcription' ,'protein oxidation' ,'mitotic cell cycle process' ,'DNA modification' ,'inflammatory response' ,'cholesterol homeostasis' ,'glutathione transferase activity' ,'autophagy' ,'fat cell differentiation' ,'triglyceride homeostasis' ,'lipid metabolic process' ,'necrotic cell death' ,'xenobiotic metabolic process' ,'negative regulation of superoxide dismutase activity' ,'triglyceride biosynthetic process' ,'cell migration' ,'cell redox homeostasis' ,'bile acid metabolic process' ,'nitric oxide biosynthetic process' ,'superoxide anion generation' ,'lactate dehydrogenase activity' ,'cell cycle' ,'amino acid metabolic process' ,'testosterone biosynthetic process' ,'activation of protein kinase B activity' ,'L-aspartate:2-oxoglutarate aminotransferase activity' ,'positive regulation of nitric oxide biosynthetic process' ,'cholesterol biosynthetic process' ,'protein import into nucleus' ,'positive regulation of protein import into nucleus' ,'wound healing, spreading of cells' ,'alkaline phosphatase activity' ,'positive regulation of cytosolic calcium ion concentration' ,'glucose homeostasis' ,'positive regulation of mitochondrial membrane potential' ,'fatty acid metabolic process' ,'cell chemotaxis' ,'positive regulation of vasoconstriction' ,'spermatogenesis' ,'positive regulation of neuron death' ,'positive regulation of superoxide dismutase activity' ,'collagen fibril organization' ,'cell differentiation' ,'histone H3-K9 acetylation' ,'mitochondrion organization' ,'positive regulation of protein localization to nucleus' ,'positive regulation of p38MAPK cascade' ,'ATP biosynthetic process' ,'metabolic process' ,'locomotion involved in locomotory behavior' ,'urate metabolic process' ,'dopamine metabolic process' ,'positive regulation of NF-kappaB transcription factor activity' ,'embryo development' ,'lipid biosynthetic process' ,'protein lipidation' ,'histamine secretion mediated by immunoglobulin' ,'glucose metabolic process' ,'negative regulation of mitochondrial membrane potential' ,'release of cytochrome c from mitochondria' ,'DNA catabolic process, endonucleolytic' ,'cellular respiration' ,'calcium ion homeostasis' ,'positive regulation of cell migration' ,'regulation of cellular metabolic process' ,'reactive nitrogen species metabolic process' ,'positive regulation of inflammatory response' ,'establishment of protein localization to plasma membrane' ,'lipid homeostasis' ,'response to antineoplastic agent' ,'glucose import' ,'urea metabolic process' ,'positive regulation of ERK1 and ERK2 cascade' ,'positive regulation of necrotic cell death' ,'memory' ,'negative regulation of glutathione peroxidase activity' ,'positive regulation of apoptotic DNA fragmentation' ,'mitochondrial depolarization' ,'G2/M transition of mitotic cell cycle' ,'cAMP metabolic process' ,'mitotic S phase' ,'hydrogen peroxide biosynthetic process' ,'positive regulation of superoxide anion generation' ,'positive regulation of autophagy' ,'protein modification process' ,'regulation of metabolic process' ,'cellular iron ion homeostasis' ,'lactate metabolic process' ,'DNA methylation on cytosine within a CG sequence' ,'apoptotic chromosome condensation' ,'serotonin metabolic process' ,'cellular lipid metabolic process' ,'positive regulation of glutathione peroxidase activity' ,'transepithelial transport' ,'positive regulation of lipid storage' ,'hydrogen peroxide metabolic process' ,'G0 to G1 transition' ,'positive regulation of collagen biosynthetic process' ,'iron ion homeostasis' ,'positive regulation of cytolysis' ,'gluconeogenesis' ,'micronucleus organization' ,'microglial cell activation' ,'positive regulation of autophagosome assembly' ,'positive regulation of NIK/NF-kappaB signaling' ,'calcium-mediated signaling' ,'positive regulation of cytokine production involved in inflammatory response' ,'cellular senescence' ,'neuron death' ,'macrophage activation' ,'cAMP biosynthetic process' ,'positive regulation of lipid catabolic process' ,'negative regulation of response to drug' ,'calcium ion import' ,'behavioral response to pain' ,'positive regulation of intracellular estrogen receptor signaling pathway' ,'regulation of bile acid metabolic process' ,'mitotic cell cycle' ,'autophagosome assembly' ,'prostaglandin metabolic process' ,'protein poly-ADP-ribosylation' ,'DNA methylation' ,'glycolytic process' ,'positive regulation of fat cell differentiation' ,'protein lipidation involved in autophagosome assembly' ,'estrogen metabolic process' ,'thyroid hormone metabolic process' ,'positive regulation of organ growth' ,'neutrophil migration' ,'NADH dehydrogenase (ubiquinone) activity' ,'prostaglandin biosynthetic process' ,'negative regulation of ATP biosynthetic process' ,'adipose tissue development' ,'larval development' ,'androgen metabolic process' ,'amino acid biosynthetic process' ,'aerobic respiration' ,'positive regulation of cellular extravasation' ,'positive regulation of neutrophil extravasation' ,'negative regulation of cell migration' ,'carbohydrate metabolic process' ,'positive regulation of JNK cascade' ,'positive regulation of neuron apoptotic process' ,'positive regulation of release of cytochrome c from mitochondria' ,'cognition' ,'vacuole organization' ,'renal sodium excretion' ,'osteoclast differentiation' ,'positive regulation of epithelial to mesenchymal transition' ,'glutathione derivative biosynthetic process' ,'arachidonic acid metabolic process' ,'neurotransmitter metabolic process' ,'stress granule assembly' ,'sperm motility' ,'hepatocyte differentiation' ,'AMP-activated protein kinase activity' ,'swimming behavior' ,'negative regulation of monooxygenase activity' ,'fatty acid homeostasis' ,'L-ascorbic acid metabolic process' ,'pyroptosis' ,'response to xenobiotic stimulus' ,'positive regulation of prostaglandin biosynthetic process' ) ) and gcr.gene_id IN ( SELECT id FROM term WHERE nm IN ( -- genes 'NOG' ,'TNF' ,'INS' ,'CASP3' ,'IL1B' ,'IL6' ,'MAPK1' ,'NFE2L2' ,'MAPK3' ,'HMOX1' ,'AHR' ,'CYP1A1' ,'PTGS2' ,'PPARA' ,'BCL2' ,'CAT' ,'ESR1' ,'BAX' ,'NOS2' ,'RELA' ,'TGFB1' ,'TP53' ,'RORA' ,'AKT1' ,'CXCL8' ,'PPARG' ,'IFNG' ,'AR' ,'INS1' ,'ACHE' ,'PARP1' ,'CASP9' ,'CCL2' ,'NQO1' ,'CDKN1A' ,'CYP3A4' ,'MMP9' ,'SOD2' ,'APP' ,'VEGFA' ,'CYP1A2' ,'CCND1' ,'FOS' ,'NFKBIA' ,'SOD1' ,'HIF1A' ,'DDIT3' ,'ESR2' ,'JUN' ,'IL10' ,'AGT' ,'FGF2' ,'ABCB1' ,'CYP2E1' ,'GPT' ,'NR1I3' ,'CYP1B1' ,'CASP8' ,'NR1I2' ,'MAPK8' ,'EGF' ,'SIRT1' ,'GSR' ,'ACTA2' ,'MPO' ,'MYC' ,'ICAM1' ,'HSPA5' ,'MMP2' ,'G3BP1' ,'STAT3' ,'SQSTM1' ,'EGFR' ,'IL4' ,'NFKB1' ,'TLR4' ,'CASP1' ,'ALB' ,'RX3' ,'CTNNB1' ,'NOS3' ,'IGF1' ,'BCL2L1' ,'COL1A1' ,'GCLC' ,'NLRP3' ,'MAP1LC3B' ,'CDH1' ,'SREBF1' ,'GSK3B' ,'MTOR' ,'FASN' ,'PCNA' ,'ABCC2' ,'STAR' ,'PGR' ,'BDNF' ,'PPARGC1A' ,'CYP19A1' ,'GPX1' ,'H2AX' ,'LEP' ,'VIM' ,'IL18' ,'OGA' ,'GSTP1' ,'ADIPOQ' ,'BECN1' ,'IL1A' ,'TRP53' ,'FAS' ,'EGR1' ,'VCAM1' ,'NR1H4' ,'NR3C1' ,'APOE' ,'ABCG2' ,'FN1' ,'MYD88' ,'IL2' ,'CXCL1' ,'FSHB' ,'CREB1' ,'EDN1' ,'BIRC5' ,'SERPINE1' ,'ABCC1' ,'CNR1' ,'ABCB11' ,'CYCS' ,'CD36' ,'TIMP1' ,'GCLM' ,'CYP2C9' ,'TNFSF10' ,'LHB' ,'TH' ,'CXCL2' ,'FABP4' ,'BCHE' ,'ATF4' ,'PON1' ,'CYP11A1' ,'SPP1' ,'CASP7' ,'HMGCR' ,'MAPK9' ,'IL12B' ,'CYP17A1' ,'CCNB1' ,'CDKN1B' ,'CYP2B6' ,'RB1' ,'PRL' ,'MAPK14' ,'CEBPB' ,'CXCL10' ,'TIPARP' ,'GADD45A' ,'XBP1' ,'ATF3' ,'TRPV1' ,'CDK1' ,'MT1' ,'LPL' ,'GJA1' ,'MKI67' ,'MAPT' ,'ADRB2' ,'PTEN' ,'TXNRD1' ,'CPT1A' ,'KEAP1' ,'CYP7A1' ,'SLC2A1' ,'CCL5' ,'RPS6KB1' ,'ACACA' ,'KCNH2' ,'CEBPA' ,'STAT1' ,'INHBA' ,'MCL1' ,'BMP4' ,'CCN2' ,'SRC' ,'CSF2' ,'PTGS1' ,'EIF2AK3' ,'XDH' ,'SNCA' ,'ABCA1' ,'CDK2' ,'GPX4' ,'THRB' ,'CNR2' ,'DRD2' ,'LDLR' ,'GSTM1' ,'ABCC3' -- chemicals ,'bisphenol A' ,'Tetrachlorodibenzodioxin' ,'Benzo(a)pyrene' ,'Valproic Acid' ,'sodium arsenite' ,'Lipopolysaccharides' ,'Estradiol' ,'Acetaminophen' ,'4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide' ,'dorsomorphin' ,'Particulate Matter' ,'Dexamethasone' ,'Cadmium Chloride' ,'titanium dioxide' ,'Aflatoxin B1' ,'Air Pollutants' ,'Cisplatin' ,'Tobacco Smoke Pollution' ,'Carbon Tetrachloride' ,'Resveratrol' ,'Doxorubicin' ,'pirinixic acid' ,'Ethinyl Estradiol' ,'Ozone' ,'Tretinoin' ,'Ethanol' ,'Dietary Fats' ,'Thioacetamide' ,'Cyclosporine' ,'Nanotubes, Carbon' ,'perfluorooctane sulfonic acid' ,'bisphenol S' ,'Folic Acid' ,'Vehicle Emissions' ,'1,2-Dimethylhydrazine' ,'Oxygen' ,'trichostatin A' ,'1-Methyl-3-isobutylxanthine' ,'Silicon Dioxide' ,'Indomethacin' ,'bisphenol F' ,'CGP 52608' ,'Atrazine' ,'Arsenic Trioxide' ,'methylmercuric chloride' ,'Cadmium' ,'Phenobarbital' ,'arsenite' ,'decamethrin' ,'Paraquat' ,'Tetradecanoylphorbol Acetate' ,'Quercetin' ,'Propylthiouracil' ,'Hydrogen Peroxide' ,'perfluorooctanoic acid' ,'Glucose' ,'Copper' ,'Smoke' ,'Chlorpyrifos' ,'triphenyl phosphate' ,'Gentamicins' ,'Diethylhexyl Phthalate' ,'Arsenic' ,'Rotenone' ,'Diethylnitrosamine' ,'Testosterone' ,'Acrylamide' ,'Phenylmercuric Acetate' ,'Dibutyl Phthalate' ,'Streptozocin' ,'Progesterone' ,'Plant Extracts' ,'Trichloroethylene' ,'aristolochic acid I' ,'Copper Sulfate' ,'cobaltous chloride' ,'Methyl Methanesulfonate' ,'Methamphetamine' ,'(+)-JQ1 compound' ,'jinfukang' ,'deoxynivalenol' ,'vinclozolin' ,'abrine' ,'Nickel' ,'Dioxins' ,'Genistein' ,'Fulvestrant' ,'Clofibrate' ,'Rosiglitazone' ,'Soot' ,'Cocaine' ,'Sunitinib' ,'Dronabinol' ,'Methotrexate' ,'JP8 aviation fuel' ,'triptonide' ,'entinostat' ,'2,2'',4,4''-tetrabromodiphenyl ether' ,'Tamoxifen' ,'Acetylcysteine' ,'1-Methyl-4-phenylpyridinium' ,'Calcitriol' ,'Acrolein' ,'di-n-butylphosphoric acid' ,'Thiram' ,'Endosulfan' ,'Zinc' ,'Ammonium Chloride' ,'Choline' ,'Ionomycin' ,'Formaldehyde' ,'tris(1,3-dichloro-2-propyl)phosphate' ,'Caffeine' ,'potassium chromate(VI)' ,'Methionine' ,'lead acetate' ,'perfluorooctanesulfonamide' ,'lipopolysaccharide, E coli O55-B5' ,'Flutamide' ,'Vorinostat' ,'furan' ,'Ivermectin' ,'Curcumin' ,'Lead' ,'Urethane' ,'Troglitazone' ,'S-(1,2-dichlorovinyl)cysteine' ,'Fluorouracil' ,'Fenretinide' ,'ethylene dichloride' ,'Dextran Sulfate' ,'hexabromocyclododecane' ,'Asbestos, Crocidolite' ,'7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide' ,'sodium arsenate' ,'manganese chloride' ,'lipopolysaccharide, Escherichia coli O111 B4' ,'Cuprizone' ,'Methapyrilene' ,'Topotecan' ,'Isoproterenol' ,'epoxiconazole' ,'FR900359' ,'Methimazole' ,'Nicotine' ,'Antirheumatic Agents' ,'3,4,5,3'',4''-pentachlorobiphenyl' ,'methacrylaldehyde' ,'chromium hexavalent ion' ,'Triclosan' ,'Glyphosate' ,'N-Methyl-3,4-methylenedioxyamphetamine' ,'mono-(2-ethylhexyl)phthalate' ,'Aluminum' ,'Oxaliplatin' ,'T-2 Toxin' ,'Cellulose' ,'Decitabine' ,'acetamide' ,'Amitrole' ,'beta-lapachone' ,'Cyclophosphamide' ,'butyraldehyde' ,'Selenium' ,'alpha-pinene' ,'Temozolomide' ,'Amiodarone' ,'4,4''-diaminodiphenylmethane' ,'1,4-bis(2-(3,5-dichloropyridyloxy))benzene' ,'Panobinostat' ,'Diethylstilbestrol' ,'decabromobiphenyl ether' ,'Tunicamycin' ,'Carbamazepine' ,'Lactic Acid' ,'Sodium Fluoride' ,'Cannabidiol' ,'ochratoxin A' ,'epigallocatechin gallate' ,'1-Naphthylisothiocyanate' ,'fipronil' ,'Mercuric Chloride' ,'Coumestrol' ,'Paclitaxel' ,'bisphenol AF' ,'tert-Butylhydroperoxide' ,'dicrotophos' ,'sulforaphane' ,'Enzyme Inhibitors' ,'Dichlorodiphenyl Dichloroethylene' ,'1H,1H,10H,10H-perfluorodecane-1,10-diol' ,'Methoxychlor' ,'Thapsigargin' ,'Leflunomide' ,'Haloperidol' ,'2,4,5,2'',4'',5''-hexachlorobiphenyl' ,'9,10-Dimethyl-1,2-benzanthracene' ,'Silver' -- diseases ,'Chemical and Drug Induced Liver Injury' ,'Seizures' ,'Hypertension' ,'Hypotension' ,'Kidney Diseases' ,'Pain' ,'Acute Kidney Injury' ,'Breast Neoplasms' ,'Necrosis' ,'Weight Loss' ,'Inflammation' ,'Drug-Related Side Effects and Adverse Reactions' ,'Cocaine-Related Disorders' ,'Heart Failure' ,'Substance Withdrawal Syndrome' ,'Depressive Disorder' ,'Bradycardia' ,'Prostatic Neoplasms' ,'Hyperalgesia' ,'Prenatal Exposure Delayed Effects' ,'Myocardial Infarction' ,'Catalepsy' ,'Liver Cirrhosis, Experimental' ,'Hyperkinesis' ,'Edema' ,'Arrhythmias, Cardiac' ,'Carcinoma, Hepatocellular' ,'Dyskinesia, Drug-Induced' ,'Nausea' ,'Vomiting' ,'Lung Neoplasms' ,'Disease Models, Animal' ,'Hyperglycemia' ,'Hepatomegaly' ,'Weight Gain' ,'Cardiomyopathies' ,'Tachycardia' ,'Headache' ,'Bipolar Disorder' ,'Nerve Degeneration' ,'Proteinuria' ,'Diabetes Mellitus, Experimental' ,'Anemia' ,'Memory Disorders' ,'Tremor' ,'Peripheral Nervous System Diseases' ,'Fatty Liver' ,'Parkinson Disease' ,'Liver Neoplasms' ,'Status Epilepticus' ,'Schizophrenia' ,'Thrombocytopenia' ,'Liver Neoplasms, Experimental' ,'Cognition Disorders' ,'Heart Diseases' ,'Hemorrhage' ,'Arthritis, Rheumatoid' ,'Renal Insufficiency' ,'Fever' ,'Asthma' ,'Cholestasis' ,'Insulin Resistance' ,'Urinary Bladder Neoplasms' ,'Obesity' ,'Nervous System Diseases' ,'Liver Cirrhosis' ,'Poisoning' ,'Muscular Diseases' ,'Diarrhea' ,'Neoplasms, Experimental' ,'Colorectal Neoplasms' ,'Atrial Fibrillation' ,'Neutropenia' ,'Tachycardia, Ventricular' ,'Anxiety Disorders' ,'Colonic Neoplasms' ,'Epilepsy' ,'Myocardial Ischemia' ,'Stomach Neoplasms' ,'Amnesia' ,'Cardiomegaly' ,'Brain Injuries' ,'Parkinsonian Disorders' ,'Diabetes Mellitus, Type 2' ,'Neoplasm Metastasis' ,'Melanoma' ,'Neoplasm Invasiveness' ,'Torsades de Pointes' ,'Neoplasms' ,'Long QT Syndrome' ,'Ventricular Dysfunction, Left' ,'Cell Transformation, Neoplastic' ,'Thrombosis' ,'Pain, Postoperative' ,'Movement Disorders' ,'Hallucinations' ,'Dystonia' ,'Nephritis, Interstitial' ,'Stomach Ulcer' ,'Carcinoma, Non-Small-Cell Lung' ,'Pulmonary Fibrosis' ,'Brain Diseases' ,'Fibrosis' ,'Learning Disabilities' ,'Heart Arrest' ,'Drug Hypersensitivity' ,'Liver Diseases' ,'Psychoses, Substance-Induced' ,'Dizziness' ,'Cardiovascular Diseases' ,'Hypokalemia' ,'Ventricular Fibrillation' ,'Autistic Disorder' ,'Precursor Cell Lymphoblastic Leukemia-Lymphoma' ,'Myoclonus' ,'Hyperplasia' ,'Precancerous Conditions' ,'Multiple Myeloma' ,'Angina Pectoris' ,'Neurotoxicity Syndromes' ,'Liver Failure, Acute' ,'Leukemia, Promyelocytic, Acute' ,'Adenocarcinoma' ,'Basal Ganglia Diseases' ,'Cystitis' ,'Hepatitis B' ,'Hepatitis' ,'Dermatitis, Allergic Contact' ,'Leukemia, Myeloid, Acute' ,'Lung Injury' ,'HIV Infections' ,'Ataxia' ,'Ovarian Neoplasms' ,'Atherosclerosis' ,'Mammary Neoplasms, Experimental' ,'Abnormalities, Drug-Induced' ,'Confusion' ,'Staphylococcal Infections' ,'Autism Spectrum Disorder' ,'Stroke' ,'Leukopenia' ,'Testicular Diseases' ,'Reperfusion Injury' ,'Colitis' ,'Alzheimer Disease' ,'Carcinoma' ,'Glucose Intolerance' ,'Skin Neoplasms' ,'Anemia, Hemolytic' ,'Exanthema' ,'Hypertension, Pulmonary' ,'Muscle Rigidity' ,'Psychotic Disorders' ,'Hypercholesterolemia' ,'Angioedema' ,'Delirium' ,'Non-alcoholic Fatty Liver Disease' ,'Paralysis' ,'Apnea' ,'Pulmonary Edema' ,'Pneumonia' ,'Micronuclei, Chromosome-Defective' ,'Venous Thrombosis' ,'Parkinson Disease, Secondary' ,'Nephrotic Syndrome' ,'Muscle Weakness' ,'Pruritus' ,'Drug Eruptions' ,'Acute Lung Injury' ,'Hypothermia' ,'Pancreatic Neoplasms' ,'Diabetic Nephropathies' ,'Gastrointestinal Diseases' ,'Substance-Related Disorders' ,'Coma' ,'Epilepsy, Tonic-Clonic' ,'Craniofacial Abnormalities' ,'Stevens-Johnson Syndrome' ,'Migraine Disorders' ,'Vision Disorders' ,'Jaundice' ,'Paresthesia' ,'Carcinoma, Squamous Cell' ,'Fatigue' ,'Cerebral Hemorrhage' ,'Hypercalcemia' ,'Skin Diseases' ,'Hypotension, Orthostatic' ,'Urticaria' ,'Hematuria' ,'Erectile Dysfunction' ,'Colitis, Ulcerative' ,'Mammary Neoplasms, Animal' ,'Lung Diseases' ,'Rhabdomyolysis' ,'Oligospermia' ,'Depressive Disorder, Major' ,'Anemia, Aplastic' ,'Anorexia' ,'Hyperlipidemias' -- phenotypes ,'apoptotic process' ,'cell population proliferation' ,'cellular metabolic process' ,'lipid oxidation' ,'glutathione metabolic process' ,'reactive oxygen species metabolic process' ,'lipid catabolic process' ,'cell death' ,'detection of oxidative stress' ,'positive regulation of apoptotic process' ,'superoxide dismutase activity' ,'positive regulation of reactive oxygen species biosynthetic process' ,'positive regulation of cell death' ,'regulation of blood pressure' ,'reactive oxygen species biosynthetic process' ,'negative regulation of cell population proliferation' ,'regulation of mitochondrial membrane potential' ,'vasoconstriction' ,'glutathione biosynthetic process' ,'membrane lipid catabolic process' ,'glutathione peroxidase activity' ,'cellular response to DNA damage stimulus' ,'cholesterol metabolic process' ,'positive regulation of cell population proliferation' ,'triglyceride metabolic process' ,'response to oxidative stress' ,'regulation of heart rate' ,'negative regulation of mitotic cell cycle' ,'vasodilation' ,'ATP metabolic process' ,'cell growth' ,'cellular calcium ion homeostasis' ,'leukocyte migration involved in inflammatory response' ,'nitric oxide metabolic process' ,'creatinine metabolic process' ,'apoptotic DNA fragmentation' ,'lipid droplet formation' ,'ncRNA transcription' ,'protein oxidation' ,'mitotic cell cycle process' ,'DNA modification' ,'inflammatory response' ,'cholesterol homeostasis' ,'glutathione transferase activity' ,'autophagy' ,'fat cell differentiation' ,'triglyceride homeostasis' ,'lipid metabolic process' ,'necrotic cell death' ,'xenobiotic metabolic process' ,'negative regulation of superoxide dismutase activity' ,'triglyceride biosynthetic process' ,'cell migration' ,'cell redox homeostasis' ,'bile acid metabolic process' ,'nitric oxide biosynthetic process' ,'superoxide anion generation' ,'lactate dehydrogenase activity' ,'cell cycle' ,'amino acid metabolic process' ,'testosterone biosynthetic process' ,'activation of protein kinase B activity' ,'L-aspartate:2-oxoglutarate aminotransferase activity' ,'positive regulation of nitric oxide biosynthetic process' ,'cholesterol biosynthetic process' ,'protein import into nucleus' ,'positive regulation of protein import into nucleus' ,'wound healing, spreading of cells' ,'alkaline phosphatase activity' ,'positive regulation of cytosolic calcium ion concentration' ,'glucose homeostasis' ,'positive regulation of mitochondrial membrane potential' ,'fatty acid metabolic process' ,'cell chemotaxis' ,'positive regulation of vasoconstriction' ,'spermatogenesis' ,'positive regulation of neuron death' ,'positive regulation of superoxide dismutase activity' ,'collagen fibril organization' ,'cell differentiation' ,'histone H3-K9 acetylation' ,'mitochondrion organization' ,'positive regulation of protein localization to nucleus' ,'positive regulation of p38MAPK cascade' ,'ATP biosynthetic process' ,'metabolic process' ,'locomotion involved in locomotory behavior' ,'urate metabolic process' ,'dopamine metabolic process' ,'positive regulation of NF-kappaB transcription factor activity' ,'embryo development' ,'lipid biosynthetic process' ,'protein lipidation' ,'histamine secretion mediated by immunoglobulin' ,'glucose metabolic process' ,'negative regulation of mitochondrial membrane potential' ,'release of cytochrome c from mitochondria' ,'DNA catabolic process, endonucleolytic' ,'cellular respiration' ,'calcium ion homeostasis' ,'positive regulation of cell migration' ,'regulation of cellular metabolic process' ,'reactive nitrogen species metabolic process' ,'positive regulation of inflammatory response' ,'establishment of protein localization to plasma membrane' ,'lipid homeostasis' ,'response to antineoplastic agent' ,'glucose import' ,'urea metabolic process' ,'positive regulation of ERK1 and ERK2 cascade' ,'positive regulation of necrotic cell death' ,'memory' ,'negative regulation of glutathione peroxidase activity' ,'positive regulation of apoptotic DNA fragmentation' ,'mitochondrial depolarization' ,'G2/M transition of mitotic cell cycle' ,'cAMP metabolic process' ,'mitotic S phase' ,'hydrogen peroxide biosynthetic process' ,'positive regulation of superoxide anion generation' ,'positive regulation of autophagy' ,'protein modification process' ,'regulation of metabolic process' ,'cellular iron ion homeostasis' ,'lactate metabolic process' ,'DNA methylation on cytosine within a CG sequence' ,'apoptotic chromosome condensation' ,'serotonin metabolic process' ,'cellular lipid metabolic process' ,'positive regulation of glutathione peroxidase activity' ,'transepithelial transport' ,'positive regulation of lipid storage' ,'hydrogen peroxide metabolic process' ,'G0 to G1 transition' ,'positive regulation of collagen biosynthetic process' ,'iron ion homeostasis' ,'positive regulation of cytolysis' ,'gluconeogenesis' ,'micronucleus organization' ,'microglial cell activation' ,'positive regulation of autophagosome assembly' ,'positive regulation of NIK/NF-kappaB signaling' ,'calcium-mediated signaling' ,'positive regulation of cytokine production involved in inflammatory response' ,'cellular senescence' ,'neuron death' ,'macrophage activation' ,'cAMP biosynthetic process' ,'positive regulation of lipid catabolic process' ,'negative regulation of response to drug' ,'calcium ion import' ,'behavioral response to pain' ,'positive regulation of intracellular estrogen receptor signaling pathway' ,'regulation of bile acid metabolic process' ,'mitotic cell cycle' ,'autophagosome assembly' ,'prostaglandin metabolic process' ,'protein poly-ADP-ribosylation' ,'DNA methylation' ,'glycolytic process' ,'positive regulation of fat cell differentiation' ,'protein lipidation involved in autophagosome assembly' ,'estrogen metabolic process' ,'thyroid hormone metabolic process' ,'positive regulation of organ growth' ,'neutrophil migration' ,'NADH dehydrogenase (ubiquinone) activity' ,'prostaglandin biosynthetic process' ,'negative regulation of ATP biosynthetic process' ,'adipose tissue development' ,'larval development' ,'androgen metabolic process' ,'amino acid biosynthetic process' ,'aerobic respiration' ,'positive regulation of cellular extravasation' ,'positive regulation of neutrophil extravasation' ,'negative regulation of cell migration' ,'carbohydrate metabolic process' ,'positive regulation of JNK cascade' ,'positive regulation of neuron apoptotic process' ,'positive regulation of release of cytochrome c from mitochondria' ,'cognition' ,'vacuole organization' ,'renal sodium excretion' ,'osteoclast differentiation' ,'positive regulation of epithelial to mesenchymal transition' ,'glutathione derivative biosynthetic process' ,'arachidonic acid metabolic process' ,'neurotransmitter metabolic process' ,'stress granule assembly' ,'sperm motility' ,'hepatocyte differentiation' ,'AMP-activated protein kinase activity' ,'swimming behavior' ,'negative regulation of monooxygenase activity' ,'fatty acid homeostasis' ,'L-ascorbic acid metabolic process' ,'pyroptosis' ,'response to xenobiotic stimulus' ,'positive regulation of prostaglandin biosynthetic process' ) ) ) and ( gcr.chem_id, gcr.gene_id ) in ( select chem_id, gene_id from tetramer );

Date: 2026-03-25 16:06:10
Duration: 8s59ms
Database: ctddev51
User: pub1
Bind query: yes

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